N³-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine

Base Information

• Chemical Name: N³-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine
• CAS No.: 1134031-93-8
• Molecular Formula: C₂₄H₃₆N₂O₇Si
• Molecular Weight: 492.645
• Mol file: 1134031-93-8.mol

Synonyms:N³-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine

Chemical Property of N³-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N³-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine

There total 5 articles about N³-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Benzyloxymethyl chloride (3587-60-8) + 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (171268-84-1) → N3-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine (1134031-93-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 ℃; for 3h;

Reference yield: 100.0%

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (171268-84-1) → N3-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine (1134031-93-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

Reference yield:

C30H50N2O7Si2 (1134031-92-7) → N3-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine (1134031-93-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at -5 ℃;

DOI:10.3987/COM-08-S(F)38

upstream raw materials:

C₃₀H₅₀N₂O₇Si₂

tert-butyldimethylsilyl chloride

5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine

Benzyloxymethyl chloride

Downstream raw materials:

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione