Potassium 1-(2,3-Epoxypropoxy)-4-naphthol Sulfate

Base Information

• Chemical Name: Potassium 1-(2,3-Epoxypropoxy)-4-naphthol Sulfate
• CAS No.: 95648-12-7
• Molecular Formula: C₁₃H₁₁O₆S*K
• Molecular Weight: 334.391
• Mol file: 95648-12-7.mol

Synonyms:1-Naphthalenol,4-(oxiranylmethoxy)-, hydrogen sulfate, potassium salt (9CI)

Chemical Property of Potassium 1-(2,3-Epoxypropoxy)-4-naphthol Sulfate

Chemical Property:

• PSA: 96.57000
• LogP: 2.53720
• Solubility.: Dimethyl Sulfoxide

Purity/Quality:

97% ^*data from raw suppliers

Potassium1-(2,3-Epoxypropoxy)-4-naphtholSulfate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Potassium 1-(2,3-Epoxypropoxy)-4-naphthol Sulfate (cas# 95648-12-7) is a compound useful in organic synthesis.

Technology Process of Potassium 1-(2,3-Epoxypropoxy)-4-naphthol Sulfate

There total 2 articles about Potassium 1-(2,3-Epoxypropoxy)-4-naphthol Sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium 1-(benzyloxy)-1-naphthol sulfate (95648-09-2) → potassium 1-(2,3-epoxypropoxy)-4-naphthol sulfate (95648-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 448 mg / H₂ / 5percent Pd/C / H₂O; propan-2-ol / 2 h / 1551.4 Torr

2: 1.) KH / 1.) DMF, RT, 5 min, 2.) DMF, CH₂Cl₂, 1 h

With hydrogen; potassium hydride; palladium on activated charcoal; In water; isopropyl alcohol;

DOI:10.1021/jm00383a023

Reference yield:

<<<(trifluoromethyl)sulfonyl>oxy>methyl>oxirane (95648-11-6) + potassium 1-hydroxy-4-naphthol sulfate (95648-10-5) → potassium 1-(2,3-epoxypropoxy)-4-naphthol sulfate (95648-12-7)

Guidance literature:

With potassium hydride; Yield given. Multistep reaction; 1.) DMF, RT, 5 min, 2.) DMF, CH₂Cl₂, 1 h;

DOI:10.1021/jm00383a023

Reference yield:

potassium 1-(2,3-epoxypropoxy)-4-naphthol sulfate (95648-12-7) + isopropylamine (75-31-0) → 4-Hydroxypropranolol sulfate (87075-33-0)

Guidance literature:

With phosphate buffer; for 19.5h; Yield given;

DOI:10.1021/jm00383a023

upstream raw materials:

<<<(trifluoromethyl)sulfonyl>oxy>methyl>oxirane

potassium 1-hydroxy-4-naphthol sulfate

potassium 1-(benzyloxy)-1-naphthol sulfate

Downstream raw materials:

4-Hydroxypropranolol sulfate

Refernces