4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tert-butyl-dimethylsilanyloxy)-phenyl]-methyl}-benzonitrile

Base Information

• Chemical Name: 4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tert-butyl-dimethylsilanyloxy)-phenyl]-methyl}-benzonitrile
• CAS No.: 216532-22-8
• Molecular Formula: C₂₉H₄₁N₃OSi
• Molecular Weight: 475.75

Synonyms:4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tert-butyl-dimethylsilanyloxy)-phenyl]-methyl}-benzonitrile

Chemical Property of 4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tert-butyl-dimethylsilanyloxy)-phenyl]-methyl}-benzonitrile

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Technology Process of 4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tert-butyl-dimethylsilanyloxy)-phenyl]-methyl}-benzonitrile

There total 4 articles about 4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tert-butyl-dimethylsilanyloxy)-phenyl]-methyl}-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-((tert-butyldimethylsilyl)oxy)phenyl)magnesium iodide + C23H26N6 → 4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tert-butyl-dimethylsilanyloxy)-phenyl]-methyl}-benzonitrile (216532-22-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

Reference yield:

1,2,3-Benzotriazole (95-14-7,27556-51-0) + 3-(tert-butyldimethylsilyloxy)phenylmagnesium bromide (117973-14-5) + 4-cyanobenzaldehyde (105-07-7) + (-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine (155836-78-5) → (+)-4-Cyano-[(R)-α-(2(S),5(R)-4-allyl-2.5-dimethyl-1-piperazinyl)-3-tert-butyldimethylsilyoxybenzyl]benzene + 4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tert-butyl-dimethylsilanyloxy)-phenyl]-methyl}-benzonitrile (216532-22-8)

Guidance literature:

With magnesium; In tetrahydrofuran; toluene;

Reference yield:

1,2,3-Benzotriazole (95-14-7,27556-51-0) + 3-(tert-butyldimethylsilyloxy)phenylmagnesium bromide (117973-14-5) + 4-cyanobenzaldehyde (105-07-7) + (-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine (155836-78-5) → 4-[(R)-a-(2(S),5(R)-4-ally-2,5-dimethyl-1-piperazinyl)-3-tert-butyldimethylsilyloxybenzyl]cyanobenzene + 4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tert-butyl-dimethylsilanyloxy)-phenyl]-methyl}-benzonitrile (216532-22-8)

Guidance literature:

With magnesium; In tetrahydrofuran; toluene;

upstream raw materials:

1,2,3-Benzotriazole

3-(tert-butyldimethylsilyloxy)phenylmagnesium bromide

4-cyanobenzaldehyde

(-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine

Downstream raw materials:

(+)-4-[(R)-1-[(2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl]-1-(3-hydroxyphenyl)methyl]benzoic Acid

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