155836-78-5

Basic information

• Product Name: Piperazine, 2,5-dimethyl-1-(2-propenyl)-, (2R,5S)- (9CI)
• Synonyms: Piperazine, 2,5-dimethyl-1-(2-propenyl)-, (2R,5S)- (9CI);(2R,5S)-2,5-DIMETHYL-1-PROP-2-EN-1-YLPIPERAZINE;(2R,5S)-2,5-DiMethyl-1-(2-propen-1-yl)piperazine;(2R-trans)-2,5-DiMethyl-1-(2-propenyl)piperazine
• CAS NO: 155836-78-5
• Molecular Formula: C₉H₁₈N₂
• Molecular Weight: 154.25262
• Product Categories: PIPERIDINE;Amines;Chiral Reagents;Heterocycles
• Mol File: 155836-78-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 205.219 °C at 760 mmHg
• Flash Point: 67.175 °C
• Appearance: /
• Density: 0.844 g/cm³
• Storage Temp.: -20°C Freezer
• CAS DataBase Reference: Piperazine, 2,5-dimethyl-1-(2-propenyl)-, (2R,5S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 2,5-dimethyl-1-(2-propenyl)-, (2R,5S)- (9CI)(155836-78-5)
• EPA Substance Registry System: Piperazine, 2,5-dimethyl-1-(2-propenyl)-, (2R,5S)- (9CI)(155836-78-5)

Safety Data

• Hazardous Substances Data: 155836-78-5(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow to light Orange Oil

Upstream product

• 106-95-6 allyl bromide 
• 2815-34-1 2,5-dimethyl-piperazine 
• 548762-65-8 (2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine 
• 548762-59-0 (2S,5R)-1-methoxycarbonyl-4-benzyloxycarbonyl-2,5-dimethylpiperazine 
• 548762-58-9 (2S,5R)-1-allyl-4-benzyloxycarbonyl-2,5-dimethylpiperazine 
• 548762-64-7 (2R,5S)-1-benzyloxycarbonyl-2,5-dimethylpiperazine 
• 548762-66-9 (2S,5R)-2,5-dimethyl-piperazine-1-carboxylic acid tert-butyl ester 
• 548762-61-4 (2S,5R)-1-methoxycarbonyl-2,5-dimethylpiperazine 
• 155836-79-6 (+)-(2S,5R)-1-allyl-2,5-dimethylpiperazine 
• 548762-67-0 (2S,5R)-1-tert-butoxycarbonyl-4-allyl-2,5-dimethylpiperazine 
• 548762-63-6 (2S,5R)-1-methoxycarbonyl-4-allyl-2,5-dimethylpiperazine 

Downstream Products

• 178803-51-5 SNC 162 
• 186094-17-7 4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide 
• 216532-22-8 4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tert-butyl-dimethylsilanyloxy)-phenyl]-methyl}-benzonitrile 
• 913645-26-8 3-[(S)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)benzotriazol-1-yl-methyl]benzoic acid methyl ester 
• 913645-24-6 4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-methyl}-N-ethyl-N-(2-triethylsilanyloxy-ethyl)-benzamide 
• 156727-74-1 (+)-4-[(αR)-α-(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamide 
• 155836-50-3 4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide 
• 419544-49-3 (-)-3-((S)-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)(thien-3-yl)methyl)phenol 
• 150428-54-9 SNC 88 

Relevant articles and documents

Anti-inflammatory piperazinyl-benzyl-tetrazole derivatives and intermediates thereof

This invention relates to tetrazoles and their pharmaceutically acceptable salts which are selective agonists for the delta opioid receptor, particularly useful in the treatment of inflammatory diseases such as arthritis, psoriasis, asthma, inflammatory bowel disease, disorders or respiratory function, gastrointestinal disorders such as functional bowel disease and functional GI disorders, of formula (I) wherein R1is H, C2-C6alkanoyl, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, (C3-C7cycloalkyl)-(C1-C4alkyl), (C1-C4alkoxy)-(C1-C4alkyl), carboxy-(C1-C4alkyl), aryl-(C1-C4alkyl) or heteroaryl-(C1-C4alkyl); R2and R3are each independently H or C1-C4alkyl; R4is selected from (i) H, (ii) a group of the formula R6—(CH2)m—Z—(CH2)n—, where m is 0, 1, 2 or 3, n is 1, 2 or 3, Z is a direct link or O, and R6is —CO2H or —CO2(C1-C4alkyl), and (iii) a group of formula (a) where R7is H or C1-C4alkyl; and R5is hydroxy, C1-C4alkoxy or —NHSO2(C1-C4alkyl); with the proviso that when Z is O, m is 1, 2 or 3 and n is 2 or 3.

Compounds as delta opioid agonists

Compounds of the formula (I)—shown below—are described. The compounds are useful in the manufacture of a pharmaceutical composition for preventing or treating inflammatory diseases such as arthritis, psoriasis, asthma, or inflammatory bowel disease, disorders of respiratory function, gastrointestinal disorders such as functional bowel disease, functional GI disorders such as irritable bowel syndrome, functional diarrhoea, functional distension, functional pain, non-ulcerogenic dyspepsia or others associated with disorders of motility or secretion, urogenital tract disorders such as incontinence, as analgesics for treating pain including non-somatic pain, or as immunosuppressants to prevent rejection in organ transplant and skin graft.

Probes for Narcotic Receptor Mediated Phenomena. 19. Synthesis of (+)-4--N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide β Opioid Receptor Agonist

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