methyl 3-((4R,6S)-8-chloro-1-cyano-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoate

Base Information

Chemical Name:methyl 3-((4R,6S)-8-chloro-1-cyano-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoate
CAS No.:937056-48-9
Molecular Formula:C₂₅H₂₃ClN₂O₅
Molecular Weight:466.921
Hs Code.:

Synonyms:methyl 3-((4R,6S)-8-chloro-1-cyano-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoate

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Chemical Property of methyl 3-((4R,6S)-8-chloro-1-cyano-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoate

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Technology Process of methyl 3-((4R,6S)-8-chloro-1-cyano-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoate

There total 12 articles about methyl 3-((4R,6S)-8-chloro-1-cyano-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189-71-5
isocyanate de chlorosulfonyle

: 937054-79-0
Methyl 3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoate

: 937056-48-9
methyl 3-((4R,6S)-8-chloro-1-cyano-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoate

Guidance literature:: In N,N-dimethyl-formamide; at -40 - 0 ℃; for 1.33333h;

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937056-48-9
methyl 3-((4R,6S)-8-chloro-1-cyano-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoate

Guidance literature:: Multi-step reaction with 11 steps

1.1: trichlorophosphate / 0.17 h / 0 - 20 °C

1.2: 2 h / 50 °C / Heating / reflux

1.3: 0.5 h / Heating / reflux

2.1: toluene / 100 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: Resolution of racemate

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

6.2: 3 h / 0 °C

7.1: triethylamine / dichloromethane / 3 h / 0 °C

8.1: dimethyl sulfoxide / 13 h / 50 °C

9.1: sodium hydroxide; water; isopropyl alcohol / 96 h / Heating / reflux

9.2: 0 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

11.1: N,N-dimethyl-formamide / 1.33 h / -40 - 0 °C

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; water; potassium carbonate; triethylamine; isopropyl alcohol; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 937057-71-1
3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionitrile

: 937056-48-9
methyl 3-((4R,6S)-8-chloro-1-cyano-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water; isopropyl alcohol / 96 h / Heating / reflux

1.2: 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: N,N-dimethyl-formamide / 1.33 h / -40 - 0 °C

With sodium hydroxide; water; potassium carbonate; isopropyl alcohol; In N,N-dimethyl-formamide;