4-benzyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one

Base Information

Chemical Name:4-benzyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:861402-69-9
Molecular Formula:C₂₃H₂₂N₂O₂
Molecular Weight:358.44
Hs Code.:

Synonyms:4-benzyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Property of 4-benzyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one

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Technology Process of 4-benzyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 7 articles about 4-benzyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 4-benzyl-3-hydroxy-1,3,4,5-tetrahydro-benzo[e][1,4]diazepin-2-one

: 5720-07-0
4-methoxyphenylboronic acid

: 861402-69-9
4-benzyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: In acetonitrile; for 4h; Heating / reflux;

Reference yield:

: 1346523-77-0
N-(2-azidobenzyl)-1-phenylmethanamine

: 861402-69-9
4-benzyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 72 h / 40 °C / Molecular sieve

2: water; trimethylphosphane / tetrahydrofuran; toluene / 0 - 20 °C

3: 5,5-dimethyl-1,3-cyclohexadiene / Reflux

With water; trimethylphosphane; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; toluene; 2: Staudinger reaction;
DOI:10.1021/jo2015054

Reference yield:

: 16714-25-3
2-azidobenzaldehyde

: 861402-69-9
4-benzyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium sulfate / dichloromethane / 3 h / 20 °C

2: sodium cyanoborohydride; acetic acid / methanol / 0 - 20 °C

3: dichloromethane / 72 h / 40 °C / Molecular sieve

4: water; trimethylphosphane / tetrahydrofuran; toluene / 0 - 20 °C

5: 5,5-dimethyl-1,3-cyclohexadiene / Reflux

With water; sodium cyanoborohydride; acetic acid; sodium sulfate; trimethylphosphane; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; toluene; 4: Staudinger reaction;
DOI:10.1021/jo2015054