tert-butyl 4-(3,4,5-trimethoxybenzoyl)-1-piperazinecarboxylate

Base Information

• Chemical Name: tert-butyl 4-(3,4,5-trimethoxybenzoyl)-1-piperazinecarboxylate
• CAS No.: 1246890-23-2
• Molecular Formula: C₁₉H₂₈N₂O₆
• Molecular Weight: 380.441
• Mol file: 1246890-23-2.mol

Synonyms:tert-butyl 4-(3,4,5-trimethoxybenzoyl)-1-piperazinecarboxylate

Chemical Property of tert-butyl 4-(3,4,5-trimethoxybenzoyl)-1-piperazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(3,4,5-trimethoxybenzoyl)-1-piperazinecarboxylate

There total 1 articles about tert-butyl 4-(3,4,5-trimethoxybenzoyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3,4,5-Trimethoxybenzoyl chloride (4521-61-3) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(3,4,5-trimethoxybenzoyl)-1-piperazinecarboxylate (1246890-23-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2010.05.041

Reference yield:

tert-butyl 4-(3,4,5-trimethoxybenzoyl)-1-piperazinecarboxylate (1246890-23-2) → piperazin-1-yl-(3,4,5,trimethoxy-phenyl)-methanone (964-65-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2010.05.041

upstream raw materials:

3,4,5-Trimethoxybenzoyl chloride

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

piperazin-1-yl-(3,4,5,trimethoxy-phenyl)-methanone