964-65-8

Upstream product

• 110-85-0 piperazine 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 1246890-23-2 tert-butyl 4-(3,4,5-trimethoxybenzoyl)-1-piperazinecarboxylate 

Downstream Products

• 137074-83-0 1-(3,4,5-Trimethoxybenzoyl)-4-(pyridin-3-ylcyanomethyl)piperazine 
• 143210-57-5 [4-(Pyridine-3-carbothioyl)-piperazin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone 
• 133261-84-4 1-(3,3-Diphenylacryloyl)-4-(3,4,5-trimethoxybenzoyl)piperazine 
• 119049-32-0 1-(3,4,5-trimethoxy-thiobenzoyl)-piperazine 
• 123947-63-7 1-(8-methoxy-2,3-dihydro-1-benzoxepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine 
• 892495-21-5 2-[4-(3,4,5-trimethoxybenzoyl)-1-piperazinomethyl]-3,5,6-trimethylpyrazine 
• 1226909-06-3 (E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one 
• 667936-06-3 6,6-bis-(4-fluoro-phenyl)-1-[4-(3,4,5,-trimethoxy-benzoyl)-piperazin-1-yl]-hex-5-en-1-one 
• 123947-21-7 1-(7-methoxy-2,3-dihydro-1-benzoxepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine 
• 151664-47-0 1-[(E)-3-Phenyl-3-(pyridin-4-yl)acryloyl]-4-(3,4,5-trimethoxybenzoyl)piperazine 
• 123947-19-3 1-(7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine 
• 123947-65-9 1-(7,8-dimethoxy-2,3-dihydro-1-benzoxepin-4-carbonyl)-4-(3, 4,5-trimethoxybenzoyl)piperazine 

Relevant academic research and scientific papers

Substituted benzoyl piperazine compound and application thereof in preparation of anti-chikungunya virus drug

The invention discloses an application of a substituted benzoyl piperazine compound in preparation of an anti-chikungunya virus drug. The substituted benzoyl piperazine compound has a structural general formula shown in the description, wherein R1, R2, R3

Substituted benzoyl piperazine compound and application thereof

The invention discloses a substituted benzoyl piperazine compound or a medicinal salt thereof. The substituted benzoyl piperazine compound has the following structural general formula, wherein definitions of substituent groups are shown in the specificati

Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents

A series of new cinnamido-pyrrolo[2,1-c][1,4]benzodiazepine conjugates (4a-d and 5a-d) and their dimers (6a-d) have been designed, synthesized and evaluated for their biological activity. The anticancer screening of compound 4a by the NCI exhibited signif

Selective reduction of secondary amides to amines in the presence of tertiary amides

Secondary amides activated with a Cbz group can be reduced to their corresponding hemiaminals using lithium borohydride. Hydrogenation then removes the Cbz and hydroxyl groups to produce the related amine. Tertiary amides are not affected.

(Pyridylcyanomethyl)piperazines as orally active PAF antagonists

A series of (pyridylcyanomethyl)piperazines was prepared and evaluated for PAF-antagonist activity. Compounds were tested in vitro in a PAF-induced platelet aggregation assay and in vivo in a PAF-induced hypotension test in normotensive rats. Oral activity was ascertained through a PAF-induced mortality test in mice. The main structure-activity trends of the series were established. Activity was mainly found in four skeletons: 1-acyl-4-(3- pyridylcyanomethyl)-piperazine, 1-acyl-4-(4-pyridylcyanomethyl)piperazine, 1- acyl-4-(3-pyridylcyanomethyl)piperidine, and 1-acyl-4-cyano-4-(3- pyridylamino)piperidine. The acyl substituents, diphenylacetyl and 3,3- diphenylpropionyl, provided the most active compounds, and the introduction of an amine or hydroxy group in the 3,3-diphenylpropionyl substituent led to further improvement in oral activity. As a result, three of the most active compounds (100, 114, and 115) have been selected for further pharmacological development.

Synthesis and CNS-depressant profile of 3,4,5-trimethoxybenzoyl analogues

A series of 3,4,5-trimethoxybenzoyl analogues with varying electronic and stereochemical characteristics has been synthesized. Many of these compounds (4, 5, 9, 12, 15) showed appreciable potentiation of pentobarbitone-induced hypnosis. Several analogues (1, 5, 6, 11, 12, 15) exhibited marked reduction of spontaneous motor activity (SMA).