5-isoxazoleacetic acid, 3-(3-cyanophenyl)-5-<<<2'-(tert-butylaminosulfonyl)<1,1'-biphenyl>-4-yl>amino>carbonyl>4,5-dihydro-, methyl ester

Base Information

Chemical Name:5-isoxazoleacetic acid, 3-(3-cyanophenyl)-5-<<<2'-(tert-butylaminosulfonyl)<1,1'-biphenyl>-4-yl>amino>carbonyl>4,5-dihydro-, methyl ester
CAS No.:193006-35-8
Molecular Formula:C₃₀H₃₀N₄O₆S
Molecular Weight:574.657
Hs Code.:

Synonyms:5-isoxazoleacetic acid, 3-(3-cyanophenyl)-5-<<<2'-(tert-butylaminosulfonyl)<1,1'-biphenyl>-4-yl>amino>carbonyl>4,5-dihydro-, methyl ester

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Chemical Property of 5-isoxazoleacetic acid, 3-(3-cyanophenyl)-5-<<<2'-(tert-butylaminosulfonyl)<1,1'-biphenyl>-4-yl>amino>carbonyl>4,5-dihydro-, methyl ester

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Technology Process of 5-isoxazoleacetic acid, 3-(3-cyanophenyl)-5-<<<2'-(tert-butylaminosulfonyl)<1,1'-biphenyl>-4-yl>amino>carbonyl>4,5-dihydro-, methyl ester

There total 10 articles about 5-isoxazoleacetic acid, 3-(3-cyanophenyl)-5-<<<2'-(tert-butylaminosulfonyl)<1,1'-biphenyl>-4-yl>amino>carbonyl>4,5-dihydro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 193006-35-8
5-isoxazoleacetic acid, 3-(3-cyanophenyl)-5-<<<2'-(tert-butylaminosulfonyl)<1,1'-biphenyl>-4-yl>amino>carbonyl>4,5-dihydro-, methyl ester

Guidance literature:

Reference yield:

: 2'-t-butylaminosulfonyl-4-amino-[1,1']-biphenyl triflouroacetic acid salt

: [5-chlorocarbonyl-3-(3-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester

: 193006-35-8
5-isoxazoleacetic acid, 3-(3-cyanophenyl)-5-<<<2'-(tert-butylaminosulfonyl)<1,1'-biphenyl>-4-yl>amino>carbonyl>4,5-dihydro-, methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

: 7338-27-4
4-methoxy-2-methylene-4-oxobutanoic acid

: 193006-35-8
5-isoxazoleacetic acid, 3-(3-cyanophenyl)-5-<<<2'-(tert-butylaminosulfonyl)<1,1'-biphenyl>-4-yl>amino>carbonyl>4,5-dihydro-, methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / aq. bleach / tetrahydrofuran / 12 h / Ambient temperature

2: SOCl₂ / acetonitrile / 1 h / Heating

3: Et₃N / tetrahydrofuran / 0.5 h / Ambient temperature

With sodium hypochlorite; thionyl chloride; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm980405i