(S)-(2RS,4S)-2-hydroxy-4-((R)-3-(4-methoxybenzyloxy)-4-methyl-1-oxoisochroman-9-yl)pentyl 2-((tert-butyldimethylsilyloxy)-methyl)pent-4-ynoate

Base Information

Chemical Name:(S)-(2RS,4S)-2-hydroxy-4-((R)-3-(4-methoxybenzyloxy)-4-methyl-1-oxoisochroman-9-yl)pentyl 2-((tert-butyldimethylsilyloxy)-methyl)pent-4-ynoate
CAS No.:1412889-82-7
Molecular Formula:C₃₅H₄₈O₈Si
Molecular Weight:624.847
Hs Code.:

Synonyms:(S)-(2RS,4S)-2-hydroxy-4-((R)-3-(4-methoxybenzyloxy)-4-methyl-1-oxoisochroman-9-yl)pentyl 2-((tert-butyldimethylsilyloxy)-methyl)pent-4-ynoate

Suppliers and Price of (S)-(2RS,4S)-2-hydroxy-4-((R)-3-(4-methoxybenzyloxy)-4-methyl-1-oxoisochroman-9-yl)pentyl 2-((tert-butyldimethylsilyloxy)-methyl)pent-4-ynoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-(2RS,4S)-2-hydroxy-4-((R)-3-(4-methoxybenzyloxy)-4-methyl-1-oxoisochroman-9-yl)pentyl 2-((tert-butyldimethylsilyloxy)-methyl)pent-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-(2RS,4S)-2-hydroxy-4-((R)-3-(4-methoxybenzyloxy)-4-methyl-1-oxoisochroman-9-yl)pentyl 2-((tert-butyldimethylsilyloxy)-methyl)pent-4-ynoate

There total 4 articles about (S)-(2RS,4S)-2-hydroxy-4-((R)-3-(4-methoxybenzyloxy)-4-methyl-1-oxoisochroman-9-yl)pentyl 2-((tert-butyldimethylsilyloxy)-methyl)pent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1278519-68-8
(R)-3-((2R,S-4S)-1,2-dihydroxypentan-4-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one

: 1412889-78-1
2-((tert-butyldimethylsilyloxy)methyl)pent-4-ynoic acid

: 1412889-82-7
(S)-(2RS,4S)-2-hydroxy-4-((R)-3-(4-methoxybenzyloxy)-4-methyl-1-oxoisochroman-9-yl)pentyl 2-((tert-butyldimethylsilyloxy)-methyl)pent-4-ynoate

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at -45 - 20 ℃; for 3.66667h;
DOI:10.1021/jo302055w

Reference yield:

: 1412889-81-6
2-((tert-butyldimethylsilyloxy)methyl)pent-4-yn-1-ol

: 1412889-82-7
(S)-(2RS,4S)-2-hydroxy-4-((R)-3-(4-methoxybenzyloxy)-4-methyl-1-oxoisochroman-9-yl)pentyl 2-((tert-butyldimethylsilyloxy)-methyl)pent-4-ynoate

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 1.08 h / 0 - 20 °C

2: 2-methyl-but-2-ene; sodium perchlorate; sodium dihydrogen phosphate monohydrate / tert-butyl alcohol; water / 20 °C

3: dmap; diisopropyl-carbodiimide / dichloromethane / 3.67 h / -45 - 20 °C

With dmap; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; sodium perchlorate; Dess-Martin periodane; diisopropyl-carbodiimide; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo302055w

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1412889-82-7
(S)-(2RS,4S)-2-hydroxy-4-((R)-3-(4-methoxybenzyloxy)-4-methyl-1-oxoisochroman-9-yl)pentyl 2-((tert-butyldimethylsilyloxy)-methyl)pent-4-ynoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

1.2: 2.5 h / 0 - 20 °C

2.1: Dess-Martin periodane / dichloromethane / 1.08 h / 0 - 20 °C

3.1: 2-methyl-but-2-ene; sodium perchlorate; sodium dihydrogen phosphate monohydrate / tert-butyl alcohol; water / 20 °C

4.1: dmap; diisopropyl-carbodiimide / dichloromethane / 3.67 h / -45 - 20 °C

With dmap; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; sodium perchlorate; sodium hydride; Dess-Martin periodane; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo302055w