7-[1-(5-methyl-2-furyl)ethyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

Base Information

Chemical Name:7-[1-(5-methyl-2-furyl)ethyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine
CAS No.:924635-53-0
Molecular Formula:C₂₂H₂₃NO₅S
Molecular Weight:413.494
Hs Code.:

Synonyms:7-[1-(5-methyl-2-furyl)ethyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

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Chemical Property of 7-[1-(5-methyl-2-furyl)ethyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

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Technology Process of 7-[1-(5-methyl-2-furyl)ethyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

There total 6 articles about 7-[1-(5-methyl-2-furyl)ethyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 871563-20-1
7-(1-hydroxyethyl)-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

: 534-22-5
2-methylfuran

: 924635-53-0
7-[1-(5-methyl-2-furyl)ethyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; Heating;
DOI:10.1016/j.tet.2006.10.056

Reference yield:

: 713502-14-8
7-acetyl-6-(4-methylsulfonylamido)-2,3-dihydro-1,4-benzodioxine

: 924635-53-0
7-[1-(5-methyl-2-furyl)ethyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NaBH₄ / ethanol / Heating

2: 75 percent / p-TsOH / CH₂Cl₂ / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2006.10.056

Reference yield:

: 493-09-4
benzo-1,4-dioxane

: 924635-53-0
7-[1-(5-methyl-2-furyl)ethyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

Guidance literature:: Multi-step reaction with 6 steps

1: AlCl₃ / benzene / 2.5 h / 55 - 60 °C

2: 56 percent / HNO₃; AcOH / 0.5 h / 0 - 20 °C

3: 65 percent / Fe; AcOH / H₂O; ethyl acetate / 6 h / Heating

4: 72 percent / pyridine / 1 h / 20 °C

5: 70 percent / NaBH₄ / ethanol / Heating

6: 75 percent / p-TsOH / CH₂Cl₂ / Heating

With pyridine; sodium tetrahydroborate; aluminium trichloride; nitric acid; iron; toluene-4-sulfonic acid; acetic acid; In ethanol; dichloromethane; water; ethyl acetate; benzene; 1: Friedel-Crafts reaction;
DOI:10.1016/j.tet.2006.10.056