tert-butyl 6-(4-fluorophenyl)-2,6-diazaspiro[3,3]heptane-2-carboxylate

Base Information

• Chemical Name: tert-butyl 6-(4-fluorophenyl)-2,6-diazaspiro[3,3]heptane-2-carboxylate
• CAS No.: 1333215-20-5
• Molecular Formula: C₁₆H₂₁FN₂O₂
• Molecular Weight: 292.353
• Mol file: 1333215-20-5.mol

Synonyms:tert-butyl 6-(4-fluorophenyl)-2,6-diazaspiro[3,3]heptane-2-carboxylate

Chemical Property of tert-butyl 6-(4-fluorophenyl)-2,6-diazaspiro[3,3]heptane-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 6-(4-fluorophenyl)-2,6-diazaspiro[3,3]heptane-2-carboxylate

There total 3 articles about tert-butyl 6-(4-fluorophenyl)-2,6-diazaspiro[3,3]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate (1041026-71-4) + 1-Chloro-4-fluorobenzene (352-33-0) → tert-butyl 6-(4-fluorophenyl)-2,6-diazaspiro[3,3]heptane-2-carboxylate (1333215-20-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; ruphos; In 1,4-dioxane; at 100 ℃; for 0.333333h;

DOI:10.1016/j.tetlet.2016.12.063

Reference yield: 48.0%

2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate (1041026-71-4) + 1-Bromo-4-fluorobenzene (460-00-4) → tert-butyl 6-(4-fluorophenyl)-2,6-diazaspiro[3,3]heptane-2-carboxylate (1333215-20-5)

Guidance literature:

With potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 110 ℃; for 24h;

Reference yield: 48.0%

2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester oxalate (1227382-01-5,1041026-71-4) + 1-Bromo-4-fluorobenzene (460-00-4) → tert-butyl 6-(4-fluorophenyl)-2,6-diazaspiro[3,3]heptane-2-carboxylate (1333215-20-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In toluene; at 110 ℃; for 24h;

upstream raw materials:

2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate

1-Bromo-4-fluorobenzene

2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester oxalate

1-Chloro-4-fluorobenzene

Downstream raw materials:

2-(4-fluorophenyl)-2,6-diazaspiro[3,3]heptane