tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate

Base Information

• Chemical Name: tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate
• CAS No.: 1227382-01-5
• Molecular Formula: C12H20N2O6
• Molecular Weight: 288.301
• Hs Code.: 2933998090
• Mol file: 1227382-01-5.mol

Synonyms:1-t-butyldimethylsilyloxy-6-bromohexane;6-bromo-1-hexanol tert-butyldimethylsilyl ether;6-bromohexyl t-butyldimethylsilyl ether;

Chemical Property of tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate

Chemical Property:

• PSA: 116.17000
• LogP: 0.24900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl2,6-Diazaspiro[3.3]heptane-2-carboxylateOxalate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate

There total 1 articles about tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl 2,6-diazaspiro[3.3]heptane-2,6-dicarboxylate (1150618-17-9) + oxalic acid (144-62-7,97993-78-7) → 2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester oxalate (1227382-01-5,1041026-71-4)

Guidance literature:

di-tert-butyl 2,6-diazaspiro[3.3]heptane-2,6-dicarboxylate; With methanol; acetyl chloride; at 20 ℃; for 20h; Inert atmosphere;

With potassium hydroxide; In methanol; at 30 ℃;

oxalic acid; In diethyl ether; at 20 ℃; for 1h;

Reference yield: 98.0%

1-phenylmethyl-4-piperidone (3612-20-2) + 2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester oxalate (1227382-01-5,1041026-71-4) → 6-(1-benzyl-piperidin-4-yl)-2,6-diaza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester

Guidance literature:

1-phenylmethyl-4-piperidone; 2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester oxalate; With acetic acid; In methanol; for 1h;

With sodium cyanoborohydride; In methanol; at 20 ℃;

Reference yield: 98.0%

2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester oxalate (1227382-01-5,1041026-71-4) + 2-cyano-4-fluorobenzoic acid methyl ester (127510-96-7) → tert-butyl 6-(3-cyano-4-(methoxycarbonyl)phenyl)-2,6-diazaspiro[3.3]heptane-2-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 110 ℃; for 2h;

upstream raw materials:

di-tert-butyl 2,6-diazaspiro[3.3]heptane-2,6-dicarboxylate

oxalic acid

Downstream raw materials:

2,6-diaza-spiro[3.3]heptane-2-carboxylic acid 2,4-dichloro-benzylamide

6-benzoyl-2,6-diaza-spiro[3.3]heptane-2-carboxylic acid 2,4-dichloro-benzylamide

6-(2,4-dichloro-benzylcarbamoyl)-2,6-diaza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester

2-(4-fluorophenyl)-2,6-diazaspiro[3,3]heptane

Refernces