C₂₄H₂₃BrN₄O₃

Base Information

• Chemical Name: C₂₄H₂₃BrN₄O₃
• CAS No.: 1251586-42-1
• Molecular Formula: C₂₄H₂₃BrN₄O₃
• Molecular Weight: 495.376
• Mol file: 1251586-42-1.mol

Synonyms:C₂₄H₂₃BrN₄O₃

Chemical Property of C₂₄H₂₃BrN₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₃BrN₄O₃

There total 6 articles about C₂₄H₂₃BrN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H12BrClN2O2 (1251581-83-5) + (S)-N-(pyrrolidin-3-yl)acetamide (114636-31-6) → C24H23BrN4O3 (1251586-42-1)

Guidance literature:

With triethylamine; In 1-methyl-pyrrolidin-2-one; at 70 ℃; for 18h;

Reference yield:

α-bromoacetophenone (70-11-1) → C24H23BrN4O3 (1251586-42-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium carbonate / acetone / 20 °C / Reflux

1.2: 2 h / Reflux

2.1: potassium carbonate / toluene / 20 °C / Inert atmosphere; Reflux

3.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 - 90 °C

4.1: ammonium acetate / 1 h / 130 °C / Air

4.2: 0.5 h / Reflux

5.1: methanesulfonyl chloride; triethylamine / dichloromethane / 18 h / 20 °C

6.1: triethylamine / 1-methyl-pyrrolidin-2-one / 18 h / 70 °C

With ammonium acetate; sodium hydride; sodium carbonate; potassium carbonate; methanesulfonyl chloride; triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; acetone; toluene;

Reference yield:

(3-amino-5-bromobenzofuran-2-yl)(phenyl)methanone (330555-74-3) → C24H23BrN4O3 (1251586-42-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / toluene / 20 °C / Inert atmosphere; Reflux

2.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 - 90 °C

3.1: ammonium acetate / 1 h / 130 °C / Air

3.2: 0.5 h / Reflux

4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 18 h / 20 °C

5.1: triethylamine / 1-methyl-pyrrolidin-2-one / 18 h / 70 °C

With ammonium acetate; sodium hydride; potassium carbonate; methanesulfonyl chloride; triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; toluene;

upstream raw materials:

C₁₈H₁₂BrClN₂O₂

(S)-N-(pyrrolidin-3-yl)acetamide

(3-amino-5-bromobenzofuran-2-yl)(phenyl)methanone

C₁₈H₁₃BrN₂O₃

Refernces