3-hydroxy-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Base Information

• Chemical Name: 3-hydroxy-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one
• CAS No.: 1491155-33-9
• Molecular Formula: C₁₆H₁₅NO₄
• Molecular Weight: 285.299
• Mol file: 1491155-33-9.mol

Synonyms:3-hydroxy-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Chemical Property of 3-hydroxy-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

There total 1 articles about 3-hydroxy-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5-methoxyisatine (39755-95-8) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 3-hydroxy-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one (1491155-33-9)

Guidance literature:

5-methoxyisatine; 4-methoxyphenyl magnesium bromide; In tetrahydrofuran; at 20 ℃; for 2h; Cooling with ice; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield: 61.8%

para-tert-butylphenol (98-54-4) + 3-hydroxy-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one (1491155-33-9) → 3-(5-tert-butyl-2-hydroxyphenyl)-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one (1491155-52-2)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; for 1.5h; Cooling with ice; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.08.030

Reference yield: 53.0%

3-hydroxy-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one (1491155-33-9) → 5-methoxy-3-(4-methoxyphenyl)indolin-2-one

Guidance literature:

With hydrogenchloride; acetic acid; tin(ll) chloride; for 4h; Reflux;

DOI:10.1021/acs.joc.1c02616

upstream raw materials:

5-methoxyisatine

4-methoxyphenyl magnesium bromide

Downstream raw materials:

3-{5-tert-butyl-2-[2-(morpholin-4-yl)ethoxy]phenyl}-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

3-(5-tert-butyl-2-hydroxyphenyl)-5-methoxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one