2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-7-phenylsulfonyl-6H-azocino[4,3-b]indol-6-one

Base Information

Chemical Name:2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-7-phenylsulfonyl-6H-azocino[4,3-b]indol-6-one
CAS No.:1271726-24-9
Molecular Formula:C₂₃H₂₄N₂O₃S
Molecular Weight:408.521
Hs Code.:

Synonyms:2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-7-phenylsulfonyl-6H-azocino[4,3-b]indol-6-one

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Chemical Property of 2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-7-phenylsulfonyl-6H-azocino[4,3-b]indol-6-one

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Technology Process of 2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-7-phenylsulfonyl-6H-azocino[4,3-b]indol-6-one

There total 7 articles about 2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-7-phenylsulfonyl-6H-azocino[4,3-b]indol-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1271726-23-8
2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-6H-azocino[4,3-b]indol-6-one

: 98-09-9
benzenesulfonyl chloride

: 1271726-24-9
2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-7-phenylsulfonyl-6H-azocino[4,3-b]indol-6-one

Guidance literature:: 2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-6H-azocino[4,3-b]indol-6-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

benzenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.3987/COM-10-S(E)5

Reference yield:

: 1271726-20-5
4-(N-(E-but-2-en-1-yl)formamido)-1-(indol-2-yl)butan-1-ol

: 1271726-24-9
2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-7-phenylsulfonyl-6H-azocino[4,3-b]indol-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 2 h / Inert atmosphere; Reflux

2.1: acetic acid / 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere

3.1: manganese(IV) oxide / dichloromethane / 72 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

With manganese(IV) oxide; sodium hydride; acetic acid; potassium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 2.1: Mannich reaction;
DOI:10.3987/COM-10-S(E)5

Reference yield:

: 1271726-26-1
4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-one

: 1271726-24-9
2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-7-phenylsulfonyl-6H-azocino[4,3-b]indol-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Inert atmosphere

2.1: disodium hydrogenphosphate; 6% sodium amalgam / methanol / 5 h / 20 °C / Inert atmosphere

3.1: acetic acid / 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere

4.1: manganese(IV) oxide / dichloromethane / 72 h / 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

5.2: 1 h / 20 °C / Inert atmosphere

With manganese(IV) oxide; sodium tetrahydroborate; disodium hydrogenphosphate; 6% sodium amalgam; sodium hydride; acetic acid; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 3.1: Mannich reaction;
DOI:10.3987/COM-10-S(E)5