(5S)-N-{(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl}-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamide

Base Information

Chemical Name:(5S)-N-{(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl}-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamide
CAS No.:1301768-05-7
Molecular Formula:C₃₀H₃₂FN₃O₆S
Molecular Weight:581.665
Hs Code.:

(5S)-N-{(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl}-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamide

Synonyms:(5S)-N-{(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl}-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamide

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Chemical Property of (5S)-N-{(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl}-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamide

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Technology Process of (5S)-N-{(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl}-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamide

There total 7 articles about (5S)-N-{(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl}-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918543-49-4
(S)-2-oxo-3-phenyloxazolidine-5-carboxylic acid

: 1309607-07-5
C₂₀H₂₅FN₂O₃S

: 1301768-05-7
(5S)-N-{(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl}-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamide

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 10 - 12h; Inert atmosphere;

Reference yield:

: 62-53-3
aniline

: 1301768-05-7
(5S)-N-{(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl}-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / water; acetone / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 3 h / 80 - 90 °C

3: sodium periodate / ruthenium(III) trichloride hydrate / tetrachloromethane; acetonitrile; water / 0 °C / Inert atmosphere

4: dicyclohexyl-carbodiimide / dichloromethane / 10 - 12 h / 20 °C / Inert atmosphere

With sodium periodate; sodium hydrogencarbonate; caesium carbonate; dicyclohexyl-carbodiimide; ruthenium(III) trichloride hydrate; In tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 3422-02-4
N-(benzyloxycarbonyl)aniline

: 1301768-05-7
(5S)-N-{(1R,2S)-1-benzyl-3-[(4S)-7-fluoro-4-methyl-1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl]-2-hydroxypropyl}-2-oxo-3-phenyl-1,3-oxazolidine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 80 - 90 °C

2: sodium periodate / ruthenium(III) trichloride hydrate / tetrachloromethane; acetonitrile; water / 0 °C / Inert atmosphere

3: dicyclohexyl-carbodiimide / dichloromethane / 10 - 12 h / 20 °C / Inert atmosphere

With sodium periodate; caesium carbonate; dicyclohexyl-carbodiimide; ruthenium(III) trichloride hydrate; In tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;