methyl 2-(S)-[(benzyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propanoate

Base Information

• Chemical Name: methyl 2-(S)-[(benzyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propanoate
• CAS No.: 950758-74-4
• Molecular Formula: C₂₃H₂₇N₃O₄
• Molecular Weight: 409.485
• Mol file: 950758-74-4.mol

Synonyms:methyl 2-(S)-[(benzyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propanoate

Chemical Property of methyl 2-(S)-[(benzyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(S)-[(benzyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propanoate

There total 5 articles about methyl 2-(S)-[(benzyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-lead-triacetate-2-methoxymethoxybenzene + (S)-methyl 2-(benzyl(methyl)amino)-3-(1H-imidazol-4-yl)propanoate (866392-18-9) → methyl 2-(S)-[(benzyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propanoate (950758-74-4)

Guidance literature:

1-lead-triacetate-2-methoxymethoxybenzene; (S)-methyl 2-(benzyl(methyl)amino)-3-(1H-imidazol-4-yl)propanoate; With copper diacetate; In dichloromethane; for 18h;

With sodium sulfide; In dichloromethane; for 0.25h; Further stages.;

DOI:10.1039/b703835f

Reference yield:

C14H15N3O2 (78640-70-7) → methyl 2-(S)-[(benzyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propanoate (950758-74-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaBH₃CN / methanol / 18 h

2.1: methanol / 5 h

2.2: 554 mg / NaBH₃CN / methanol / 18 h

3.1: Cu(OAc)2 / CH₂Cl₂ / 18 h

3.2: 85 percent / Na₂S / CH₂Cl₂ / 0.25 h

With copper diacetate; sodium cyanoborohydride; In methanol; dichloromethane;

DOI:10.1039/b703835f

Reference yield:

benzaldehyde (100-52-7) → methyl 2-(S)-[(benzyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propanoate (950758-74-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: methanol / 1 h

2.1: NaBH₃CN / methanol / 18 h

3.1: methanol / 5 h

3.2: 554 mg / NaBH₃CN / methanol / 18 h

4.1: Cu(OAc)2 / CH₂Cl₂ / 18 h

4.2: 85 percent / Na₂S / CH₂Cl₂ / 0.25 h

With copper diacetate; sodium cyanoborohydride; In methanol; dichloromethane;

DOI:10.1039/b703835f

upstream raw materials:

(S)-methyl 2-(benzyl(methyl)amino)-3-(1H-imidazol-4-yl)propanoate

C₁₄H₁₅N₃O₂

benzaldehyde

L-Histidine methyl ester

Downstream raw materials:

methyl 2-(S)-(methylamino)-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propanoate

Refernces