2,6-dimethyl4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester

Base Information

• Chemical Name: 2,6-dimethyl4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester
• CAS No.: 129904-66-1
• Molecular Formula: C₂₃H₂₂N₄O₇
• Molecular Weight: 466.45
• Mol file: 129904-66-1.mol

Synonyms:2,6-dimethyl4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester

Chemical Property of 2,6-dimethyl4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dimethyl4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester

There total 7 articles about 2,6-dimethyl4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-cyanoethyl 2-(nicotinoylamino)ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (167409-41-8) → 2,6-dimethyl4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester (129904-66-1)

Guidance literature:

With sodium sulfide; In methanol; dichloromethane; for 5h; Ambient temperature;

DOI:10.1248/cpb.42.1579

Reference yield:

3-nitro-benzaldehyde (99-61-6) + (Z)-3-Amino-but-2-enoic acid 2-cyano-ethyl ester (193539-61-6) + 2-(nicotinoylamino)ethyl acetoacetate (129904-65-0) → 2,6-dimethyl4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester (129904-66-1)

Guidance literature:

With hydrogenchloride; sodium hydroxide; piperdinium acetate; In acetone;

Reference yield:

methyl 3-pyridinecarboxylate (93-60-7) → 2,6-dimethyl4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester (129904-66-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / 0.5 h / 50 °C

2: 90 percent / tetrahydrofuran / 3 h / 50 - 60 °C

3: 80 percent / propan-2-ol / 5 h / Heating

4: 91 percent / Na₂S / methanol; CH₂Cl₂ / 5 h / Ambient temperature

With sodium sulfide; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;

DOI:10.1248/cpb.42.1579

upstream raw materials:

2-cyanoethyl 2-(nicotinoylamino)ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

methyl 3-pyridinecarboxylate

N-(2-hydroxyethyl)nicotinamide

2-(nicotinoylamino)ethyl-3-aminocrotonate