(5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-(methoxyimino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one

Base Information

Chemical Name:(5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-(methoxyimino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one
CAS No.:1395322-99-2
Molecular Formula:C₂₀H₂₃FN₆O₃
Molecular Weight:414.439
Hs Code.:

Synonyms:(5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-(methoxyimino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one

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Chemical Property of (5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-(methoxyimino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one

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Technology Process of (5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-(methoxyimino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one

There total 13 articles about (5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-(methoxyimino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1395322-95-8
(5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-oxohexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one

: 593-56-6
N-methoxylamine hydrochloride

: 1395322-99-2
(5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-(methoxyimino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one

Guidance literature:: With sodium hydrogencarbonate; In water; at 20 ℃; for 48h;

Reference yield: 92.0%

: 1395322-97-0
(5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-(hydroxyimino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one

: 593-56-6
N-methoxylamine hydrochloride

: 1395322-99-2
(5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-(methoxyimino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one

Guidance literature:: With sodium hydrogencarbonate; In ethanol; water; at 20 ℃; for 48h;
DOI:10.1111/j.1747-0285.2012.01404.x

Reference yield:

: 1395322-86-7
2-(2-fluoro-4-nitrophenyl)-5-oxohexahydrocyclopenta[c]pyrrole

: 1395322-99-2
(5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-(methoxyimino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene-4-sulfonic acid / water; benzene / 3 h / Reflux; Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h / 20 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

4.2: 12 h / -78 - 20 °C

5.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

6.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C

7.1: 48 h / Reflux

8.1: toluene-4-sulfonic acid / water; acetone / 6 h / Reflux

9.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol; water / 18 h / 20 °C

10.1: sodium hydrogencarbonate / ethanol; water / 48 h / 20 °C

With n-butyllithium; sodium azide; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1111/j.1747-0285.2012.01404.x