(2S,4S)-2-amino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane dioic acid

Base Information

Chemical Name:(2S,4S)-2-amino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane dioic acid
CAS No.:1196861-69-4
Molecular Formula:C₁₃H₁₃F₄NO₄
Molecular Weight:323.244
Hs Code.:

Synonyms:(2S,4S)-2-amino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane dioic acid

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Chemical Property of (2S,4S)-2-amino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane dioic acid

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Technology Process of (2S,4S)-2-amino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane dioic acid

There total 2 articles about (2S,4S)-2-amino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane dioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1196861-66-1
(2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester

: 1196861-69-4
(2S,4S)-2-amino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane dioic acid

Guidance literature:: (2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester; With hydrogenchloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 48h;

With sodium hydroxide; In water; pH=7.4;

Reference yield:

: di-tert-butyl (N-tert-butoxycarbonyl)-L-glutamate

: 220239-69-0
2-(bromomethyl)-1-fluoro-4-(trifluoromethyl)benzene

: 1196861-69-4
(2S,4S)-2-amino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane dioic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.67 h / -70 °C

1.2: -70 °C

2.1: hydrogenchloride / tetrahydrofuran; diethyl ether / 48 h / 20 °C

2.2: pH 7.4

With hydrogenchloride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether;