(2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester

Base Information

Chemical Name:(2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester
CAS No.:1196861-66-1
Molecular Formula:C₂₆H₃₇F₄NO₆
Molecular Weight:535.576
Hs Code.:

Synonyms:(2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester

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Chemical Property of (2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester

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Technology Process of (2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester

There total 2 articles about (2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.3%

: di-tert-butyl (N-tert-butoxycarbonyl)-L-glutamate

: 220239-69-0
2-(bromomethyl)-1-fluoro-4-(trifluoromethyl)benzene

: 1196861-66-1
(2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester

Guidance literature:: di-tert-butyl (N-tert-butoxycarbonyl)-L-glutamate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -70 ℃; for 2.66667h;

2-(bromomethyl)-1-fluoro-4-(trifluoromethyl)benzene; In tetrahydrofuran; at -70 ℃;

Reference yield:

: di-tert-butyl (N-tert-butoxycarbonyl)-L-glutamate

: 220239-69-0
2-(bromomethyl)-1-fluoro-4-(trifluoromethyl)benzene

: 4039-32-1
lithium hexamethyldisilazane

: 1196861-66-1
(2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; dichloromethane;

Reference yield: 97.0%

: 1196861-66-1
(2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester

: 1196861-69-4
(2S,4S)-2-amino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane dioic acid

Guidance literature:: (2S,4S)-2-tert-butoxycarbonylamino-4-(2-fluoro-5-trifluoromethyl-benzyl)-pentane-dioic acid di-tert-butyl ester; With hydrogenchloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 48h;

With sodium hydroxide; In water; pH=7.4;