(Z)-ethyl α-<<3-<(1,1-dimethylethyl)dimethylsiloxy>phenyl>methylene>-4,5-diphenyl-2-oxazoleacetate

Base Information

• Chemical Name: (Z)-ethyl α-<<3-<(1,1-dimethylethyl)dimethylsiloxy>phenyl>methylene>-4,5-diphenyl-2-oxazoleacetate
• CAS No.: 147594-03-4
• Molecular Formula: C₃₂H₃₅NO₄Si
• Molecular Weight: 525.72
• Mol file: 147594-03-4.mol

Synonyms:(Z)-ethyl α-<<3-<(1,1-dimethylethyl)dimethylsiloxy>phenyl>methylene>-4,5-diphenyl-2-oxazoleacetate

Chemical Property of (Z)-ethyl α-<<3-<(1,1-dimethylethyl)dimethylsiloxy>phenyl>methylene>-4,5-diphenyl-2-oxazoleacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-ethyl α-<<3-<(1,1-dimethylethyl)dimethylsiloxy>phenyl>methylene>-4,5-diphenyl-2-oxazoleacetate

There total 3 articles about (Z)-ethyl α-<<3-<(1,1-dimethylethyl)dimethylsiloxy>phenyl>methylene>-4,5-diphenyl-2-oxazoleacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

ethyl 4,5-diphenyl-2-oxazoleacetate (26820-93-9) + 3-(tert-butyl-dimethyl-sylanyloxy)benzaldehyde (96013-95-5) → (E)-ethyl α-<<3-<(1,1-dimethylethyl)dimethylsiloxy>phenyl>methylene>-4,5-diphenyl-2-oxazoleacetate (147594-02-3) + (Z)-ethyl α-<<3-<(1,1-dimethylethyl)dimethylsiloxy>phenyl>methylene>-4,5-diphenyl-2-oxazoleacetate (147594-03-4)

Guidance literature:

With piperidine; toluene-4-sulfonic acid; In toluene; for 3h; Heating;

DOI:10.1021/jm00076a017

Reference yield:

2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) → (Z)-ethyl α-<<3-<(1,1-dimethylethyl)dimethylsiloxy>phenyl>methylene>-4,5-diphenyl-2-oxazoleacetate (147594-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 4-(dimethylamino)pyridine, pyridine, 2.) AcOH, NH₄OAc / 1.) CH₂Cl₂, a) 10 deg C, 30 min, b) RT, 2 h, 2.) reflux, 2 h

2: 30 percent / piperidine, p-TsOH / toluene / 3 h / Heating

With piperidine; pyridine; dmap; ammonium acetate; toluene-4-sulfonic acid; acetic acid; In toluene;

DOI:10.1021/jm00076a017

Reference yield:

ethyl chlorocarbonylacetate (36239-09-5) → (Z)-ethyl α-<<3-<(1,1-dimethylethyl)dimethylsiloxy>phenyl>methylene>-4,5-diphenyl-2-oxazoleacetate (147594-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 4-(dimethylamino)pyridine, pyridine, 2.) AcOH, NH₄OAc / 1.) CH₂Cl₂, a) 10 deg C, 30 min, b) RT, 2 h, 2.) reflux, 2 h

2: 30 percent / piperidine, p-TsOH / toluene / 3 h / Heating

With piperidine; pyridine; dmap; ammonium acetate; toluene-4-sulfonic acid; acetic acid; In toluene;

DOI:10.1021/jm00076a017

upstream raw materials:

ethyl 4,5-diphenyl-2-oxazoleacetate

3-(tert-butyl-dimethyl-sylanyloxy)benzaldehyde

2-hydroxy-2-phenylacetophenone

ethyl chlorocarbonylacetate