(2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid

Base Information

Chemical Name:(2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid
CAS No.:103700-11-4
Molecular Formula:C₁₇H₂₅NO₃Si
Molecular Weight:319.476
Hs Code.:

Synonyms:(2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid

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Chemical Property of (2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid

Chemical Property:

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Technology Process of (2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid

There total 1 articles about (2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82938-50-9,162856-35-1
(4S)-N-tert-butyldimethylsilylazetidin-2-one-4-carboxylic acid

: 100-39-0
benzyl bromide

: 103700-11-4
(2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid

Guidance literature:: (4S)-N-tert-butyldimethylsilylazetidin-2-one-4-carboxylic acid; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene;

benzyl bromide; In tetrahydrofuran; n-heptane; ethylbenzene;
DOI:10.1016/S0968-0896(01)00209-7

Reference yield:

: 103700-11-4
(2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid

: 684262-83-7
4-((2R,3R)-3-Benzyl-4-oxo-azetidin-2-yloxy)-benzoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide; acetic acid

2: tetrabutylammonium fluoride / tetrahydrofuran / 25 °C

3: aq. NaOH / acetone

With sodium hydroxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0968-0896(01)00209-7

Reference yield:

: 103700-11-4
(2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid

: 256410-14-7
4-[(2R,3R)-3-Benzyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylformamide; acetic acid

2: tetrabutylammonium fluoride / tetrahydrofuran / 25 °C

3: aq. NaOH / acetone

4: Et₃N; DMAP / CH₂Cl₂ / 20 °C

5: trifluoroacetic acid; anisole

With dmap; sodium hydroxide; tetrabutyl ammonium fluoride; methoxybenzene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0968-0896(01)00209-7