S-(-)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:S-(-)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:73445-62-2
Molecular Formula:C₁₈H₂₀ClNO
Molecular Weight:301.816
Hs Code.:

Synonyms:S-(-)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Chemical Property of S-(-)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of S-(-)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 8 articles about S-(-)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 131615-56-0
S-(-)-7-chloro-8-methoxy-1-(3'-bromophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 73445-62-2
S-(-)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; for 16h; under 760 Torr; Ambient temperature;
DOI:10.1021/jm00107a002

Reference yield:

: 28022-44-8,131567-05-0
2-(3-bromophenyl)oxirane

: 73445-62-2
S-(-)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 53 percent

2: H₂SO₄ / 2 h / 0 - 20 °C

4: 87 percent / HCO₂H / H₂O / 4 h / 90 - 100 °C

5: 51 percent / H₂, Et₃N / 5percent Pd/C / tetrahydrofuran / 16 h / 760 Torr / Ambient temperature

With formic acid; sulfuric acid; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; water;
DOI:10.1021/jm00107a002

Reference yield:

: 7569-87-1
3-chloro-4-methoxyphenethylamine

: 73445-62-2
S-(-)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 53 percent

2: H₂SO₄ / 2 h / 0 - 20 °C

4: 87 percent / HCO₂H / H₂O / 4 h / 90 - 100 °C

5: 51 percent / H₂, Et₃N / 5percent Pd/C / tetrahydrofuran / 16 h / 760 Torr / Ambient temperature

With formic acid; sulfuric acid; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; water;
DOI:10.1021/jm00107a002