1-(3-Bromo-phenyl)-2-[2-(3-chloro-4-methoxy-phenyl)-ethylamino]-ethanol

Base Information

• Chemical Name: 1-(3-Bromo-phenyl)-2-[2-(3-chloro-4-methoxy-phenyl)-ethylamino]-ethanol
• CAS No.: 131567-06-1
• Molecular Formula: C₁₇H₁₉BrClNO₂
• Molecular Weight: 384.7
• Mol file: 131567-06-1.mol

Synonyms:1-(3-Bromo-phenyl)-2-[2-(3-chloro-4-methoxy-phenyl)-ethylamino]-ethanol

Chemical Property of 1-(3-Bromo-phenyl)-2-[2-(3-chloro-4-methoxy-phenyl)-ethylamino]-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-Bromo-phenyl)-2-[2-(3-chloro-4-methoxy-phenyl)-ethylamino]-ethanol

There total 2 articles about 1-(3-Bromo-phenyl)-2-[2-(3-chloro-4-methoxy-phenyl)-ethylamino]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-(3-bromophenyl)oxirane (28022-44-8,131567-05-0) + 3-chloro-4-methoxyphenethylamine (7569-87-1) → 1-(3-Bromo-phenyl)-2-[2-(3-chloro-4-methoxy-phenyl)-ethylamino]-ethanol (131567-06-1)

Guidance literature:

DOI:10.1021/jm00107a002

Reference yield:

4-Methoxyphenethylamine (55-81-2) → 1-(3-Bromo-phenyl)-2-[2-(3-chloro-4-methoxy-phenyl)-ethylamino]-ethanol (131567-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / Cl₂, AcOH

2: 53 percent

With chlorine; acetic acid;

DOI:10.1021/jm00107a002

Reference yield:

1-(3-Bromo-phenyl)-2-[2-(3-chloro-4-methoxy-phenyl)-ethylamino]-ethanol (131567-06-1) → R-(+)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (129666-34-8)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂SO₄ / 2 h / 0 - 20 °C

3: 82 percent / HCO₂H / H₂O / 4 h / 90 - 100 °C

4: 59 percent / H₂, Et₃N / 5percent Pd/C / tetrahydrofuran / 16 h / 760 Torr / Ambient temperature

With formic acid; sulfuric acid; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; water;

DOI:10.1021/jm00107a002

upstream raw materials:

2-(3-bromophenyl)oxirane

3-chloro-4-methoxyphenethylamine

4-Methoxyphenethylamine

Downstream raw materials:

(+/-)-7-chloro-8-methoxy-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

R-(+)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

S-(-)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

R-(+)-7-chloro-8-methoxy-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine