benzyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate

Base Information

• Chemical Name: benzyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate
• CAS No.: 312944-15-3
• Molecular Formula: C₁₉H₁₇ClN₂O₃
• Molecular Weight: 356.809

Synonyms:benzyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate

Chemical Property of benzyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate

Chemical Property:

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Technology Process of benzyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate

There total 2 articles about benzyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

benzyl acetoacetate (5396-89-4) + 4-chlorobenzaldehyde (104-88-1) + urea (57-13-6) → benzyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate (312944-15-3)

Guidance literature:

With cobalt hydrogen sulfate; In ethanol; Reflux;

DOI:10.1002/cbdv.201700502

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → benzyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate (312944-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / Reflux

2: cobalt hydrogen sulfate / ethanol / Reflux

With cobalt hydrogen sulfate; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol;

DOI:10.1002/cbdv.201700502

Reference yield: 84.0%

benzyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate (312944-15-3) → 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxodropyrimidine-5-carboxylic acid (891190-52-6)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.07.093

upstream raw materials:

benzyl acetoacetate

4-chlorobenzaldehyde

urea

benzyl alcohol

Downstream raw materials:

4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxodropyrimidine-5-carboxylic acid

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