ethyl 8-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

Base Information

Chemical Name:ethyl 8-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate
CAS No.:1371630-31-7
Molecular Formula:C₂₈H₃₁FN₂O₅
Molecular Weight:494.563
Hs Code.:

Synonyms:ethyl 8-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

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Chemical Property of ethyl 8-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

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Technology Process of ethyl 8-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

There total 1 articles about ethyl 8-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 489446-42-6
4-((tert-butoxycarbonylamino)methyl)phenylboronic acid

: 169749-89-7
8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester

: 1371630-31-7
ethyl 8-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 90 ℃; for 1h; Product distribution / selectivity; Inert atmosphere;

Reference yield: 95.0%

: 1371630-31-7
ethyl 8-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

: 1371630-32-8
8-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 30 ℃; for 18h;

Reference yield: 52.0%

: 1371630-31-7
ethyl 8-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

: 508224-95-1
8-(4-(aminomethyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-quinolizine-3-carboxylic acid

Guidance literature:: ethyl 8-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate; With water; sodium hydroxide; In tetrahydrofuran; at 120 ℃; for 0.166667h; microwave irradiation;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;