169749-89-7

Basic information

• Product Name: 4H-Quinolizine-3-carboxylic acid, 8-chloro-1-cyclopropyl-7-fluoro-9-Methyl-4-oxo-, ethyl ester
• Synonyms: 4H-Quinolizine-3-carboxylic acid, 8-chloro-1-cyclopropyl-7-fluoro-9-Methyl-4-oxo-, ethyl ester;ethyl 8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate;8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester;EOS-61939
• CAS NO: 169749-89-7
• Molecular Formula: C₁₆H₁₅ClFNO₃
• Molecular Weight: 323.7466032
• Mol File: 169749-89-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4H-Quinolizine-3-carboxylic acid, 8-chloro-1-cyclopropyl-7-fluoro-9-Methyl-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Quinolizine-3-carboxylic acid, 8-chloro-1-cyclopropyl-7-fluoro-9-Methyl-4-oxo-, ethyl ester(169749-89-7)
• EPA Substance Registry System: 4H-Quinolizine-3-carboxylic acid, 8-chloro-1-cyclopropyl-7-fluoro-9-Methyl-4-oxo-, ethyl ester(169749-89-7)

Safety Data

• Hazardous Substances Data: 169749-89-7(Hazardous Substances Data)

Usage

General Description

The chemical "4H-Quinolizine-3-carboxylic acid, 8-chloro-1-cyclopropyl-7-fluoro-9-Methyl-4-oxo-, ethyl ester" is an ester of a quinolizinecarboxylic acid derivative with a chloro, cyclopropyl, fluoro, and methyl functional groups. It is a synthetic compound that is commonly used in chemical and pharmaceutical research. This chemical may have potential applications in the development of new drugs and medication formulations due to its unique structure and properties. However, further research and testing are needed to fully understand its potential uses and effects.

Upstream product

• 200188-13-2 ethyl 8-hydroxy-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate 
• 84476-99-3 2,5-difluoropyridine 
• 851386-40-8 4-chloro-2,5-difluoropyridine 
• 169749-88-6 2-(4-chloro-5-fluoro-3-methyl-2-pyridinyl)-2-cyclopropylacetaldehyde 
• 105-53-3 diethyl malonate 
• 438238-05-2 2-(4-hydroxy-5-fluoro-3-methyl-2-pyridinyl)cyclopropaneacetonitrile 
• 169749-81-9 4-tert-butoxy-3-chloro-2,5,6-trifluoropyridine 
• 169749-82-0 4-t-Butoxy-2,3,6-trifluoropyridine 
• 1735-84-8 3-chloro-2,4,5,6-tetrafluoropyridine 
• 169749-87-5 2-(4-chloro-5-fluoro-3-methyl-2-pyridinyl)-2-cyclopropylacetic acid,ethyl ester 
• 169749-85-3 2-(4-tert-butoxy-5-fluoro-3-methyl-2-pyridinyl)-2-cyclopropylacetonitrile 
• 169749-86-4 2-(4-chloro-5-fluoro-3-methylpyridin-2-yl)-2-cyclopropylacetonitrile 
• 169750-50-9 2-(4-chloro-5-fluoro-3-methyl-2-pyridinyl)-2-cyclopropylethanol 

Downstream Products

• 1026011-56-2 8-((3aR,6aR)-1-Benzyloxycarbonyl-hexahydro-pyrrolo[3,4-b]pyrrol-5-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester 
• 1371629-49-0 8-(4-carboxyphenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid 
• 1371629-41-2 potassium 8-(4-(aminomethyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate 
• 1371629-14-9 8-(3-aminophenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid 
• 1371630-03-3 ethyl 8-(4-carbamoylphenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate 
• 1371630-02-2 ethyl 8-(4-aminophenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate 
• 1371629-98-9 ethyl 8-(4-amino-3-fluorophenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate 
• 1371629-18-3 potassium 8-(4-carbamoylphenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate 
• 1371629-17-2 8-(4-carbamoylphenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid 
• 1371629-16-1 potassium 8-(4-aminophenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate 
• 1371629-15-0 8-(4-aminophenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid 
• 1371629-12-7 potassium 8-(4-amino-3-fluorophenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate 
• 1371629-11-6 8-(4-amino-3-fluorophenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-quinolizine-3-carboxylic acid 
• 508224-95-1 8-(4-(aminomethyl)phenyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-quinolizine-3-carboxylic acid 

Relevant articles and documents

Preparation and antibacterial activity of pyridopyridone analogs: C-1 modifications

Variation of the C-1 position of the pyridopyridone antibacterials shows a sensitivity to both size and electronic character of the substituent.

8-chloro-1-cyclopropyl-7-fluorine-9-methyl-4-oxygen-4-hydrogen-quinolizine-3-carboxylic ester and preparation method thereof

The invention provides a preparation method of 8-chloro-1-cyclopropyl-7-fluorine-9-methyl-4-oxygen-4-hydrogen-quinolizine-3-carboxylic ester. The preparation method comprises the following steps: step one, enabling 2, 5-difluoropyridine and chlorine supply compound to react in a non-protonic solvent, and obtaining 4-chloro-2, 5-difluoropyridine; step two, enabling 4-chloro-2, 5-difluoropyridine and methyl donor to react in a non-protonic solvent, and obtaining 4-chloro-2, 5-difluoro-3-methylpyridine; step three, enabling 4-chloro-2, 5-difluoro-3-methylpyridine and cyclopropyl acetonitrile to react under the effect of strong base, and obtaining 2-(4-chloro-5-fluorine-3-methylpyridine-2-base)-2-cyclopropylacetonitrile; step four, preparing 2-(4-chloro-5-fluorine-3-methylpyridine-2-base)-2-cyclopropyl acetaldehyde; step five, enabling 2-(4-chloro-5-fluorine-3-methylpyridine-2-base)-2-cyclopropyl acetaldehyde and malonic ester to react, and obtaining 8-chloro-1-cyclopropyl-7-fluorine-9-methyl-4-oxygen-4-hydrogen-quinolizine-3-carboxylic ester. The method can reduce the synthesis steps of final products, and reduce the preparation cost.

Pyridone antibiotic with improved safety profile

Antibacterial compounds having the formula STR1 and the pharmaceutically acceptable salts, esters and amides thereof, as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.