methyl 3α,12α-bis<3-(4-N-tosylaminophenyl)propanoyloxy>-5β-cholan-24-oate

Base Information

• Chemical Name: methyl 3α,12α-bis<3-(4-N-tosylaminophenyl)propanoyloxy>-5β-cholan-24-oate
• CAS No.: 162850-18-2
• Molecular Formula: C₅₇H₇₂N₂O₁₀S₂
• Molecular Weight: 1009.34
• Mol file: 162850-18-2.mol

Synonyms:methyl 3α,12α-bis<3-(4-N-tosylaminophenyl)propanoyloxy>-5β-cholan-24-oate

Chemical Property of methyl 3α,12α-bis<3-(4-N-tosylaminophenyl)propanoyloxy>-5β-cholan-24-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3α,12α-bis<3-(4-N-tosylaminophenyl)propanoyloxy>-5β-cholan-24-oate

There total 3 articles about methyl 3α,12α-bis<3-(4-N-tosylaminophenyl)propanoyloxy>-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

p-toluenesulfonyl chloride (98-59-9) + methyl 3α,12α-bis<3-(4-aminophenyl)propanoyloxy>-5β-cholan-24-oate (162850-17-1) → methyl 3α,12α-bis<3-(4-N-tosylaminophenyl)propanoyloxy>-5β-cholan-24-oate (162850-18-2)

Guidance literature:

With dmap; In pyridine; at 120 ℃; for 24h;

Reference yield:

3-(p-nitrophenyl)propanoyl chloride (107324-93-6) → methyl 3α,12α-bis<3-(4-N-tosylaminophenyl)propanoyloxy>-5β-cholan-24-oate (162850-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / CaH₂, benzyltriethylammonium chloride / toluene / 20 h / 90 °C

2: 85.4 percent / SnCl₂*2H₂O / ethyl acetate / 2 h / 60 °C

3: 55 percent / 4-(dimethylamino)pyridine / pyridine / 24 h / 120 °C

With dmap; calcium hydride; N-benzyl-N,N,N-triethylammonium chloride; tin(ll) chloride; In pyridine; ethyl acetate; toluene;

Reference yield:

methyl 3α,12α-bis-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate (162850-16-0) → methyl 3α,12α-bis<3-(4-N-tosylaminophenyl)propanoyloxy>-5β-cholan-24-oate (162850-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85.4 percent / SnCl₂*2H₂O / ethyl acetate / 2 h / 60 °C

2: 55 percent / 4-(dimethylamino)pyridine / pyridine / 24 h / 120 °C

With dmap; tin(ll) chloride; In pyridine; ethyl acetate;

upstream raw materials:

p-toluenesulfonyl chloride

methyl 3α,12α-bis<3-(4-aminophenyl)propanoyloxy>-5β-cholan-24-oate

3-(p-nitrophenyl)propanoyl chloride

methyl 3α,12α-bis-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate