4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Base Information

• Chemical Name: 4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide
• CAS No.: 1318133-07-1
• Molecular Formula: C₁₅H₁₂F₂N₄O₃S
• Molecular Weight: 366.348
• Mol file: 1318133-07-1.mol

Synonyms:4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Chemical Property of 4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

There total 9 articles about 4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide (1318133-05-9) → 4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide (1318133-07-1)

Guidance literature:

With ammonia; In isopropyl alcohol; at 70 ℃; for 10h; closed vessel;

Reference yield:

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester (85006-31-1) → 4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide (1318133-07-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 3 h / 200 °C

2: trichlorophosphate / 2 h / 110 °C

3: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 1 h / 100 °C

4: potassium iodide / N,N-dimethyl-formamide / 4 h / 35 °C

5: sodium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

6: manganese(IV) oxide / chloroform / 2 h / 70 °C

7: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide / 0 - 20 °C

8: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

9: ammonia / isopropyl alcohol / 10 h / 70 °C / closed vessel

With manganese(IV) oxide; sodium chlorite; N-Bromosuccinimide; sodium dihydrogenphosphate dihydrate; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; sodium hydroxide; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

7-(bromomethyl)-4-chlorothieno[3,2-d]pyrimidine (209286-57-7) → 4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide (1318133-07-1)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium iodide / N,N-dimethyl-formamide / 4 h / 35 °C

2: sodium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

3: manganese(IV) oxide / chloroform / 2 h / 70 °C

4: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide / 0 - 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

6: ammonia / isopropyl alcohol / 10 h / 70 °C / closed vessel

With manganese(IV) oxide; sodium chlorite; sodium dihydrogenphosphate dihydrate; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; sodium hydroxide; In tetrahydrofuran; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

upstream raw materials:

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

7-(bromomethyl)-4-chlorothieno[3,2-d]pyrimidine

7-methyl-3,4-dihydrothieno[3,2-d]pyrimidin-4-one

4-chloro-7-methylthieno[3,2-d]pyrimidine

Downstream raw materials:

4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide