4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Base Information

Chemical Name:4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide
CAS No.:1318128-97-0
Molecular Formula:C₁₈H₁₆F₂N₄O₃S
Molecular Weight:406.413
Hs Code.:

Synonyms:4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

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Chemical Property of 4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

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Technology Process of 4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

There total 11 articles about 4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318133-07-1
4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

: 765-30-0
Cyclopropylamine

: 1318128-97-0
4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: In isopropyl alcohol; at 110 ℃; for 15h;

Reference yield:

: 1318133-05-9
4-chloro-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

: 765-30-0
Cyclopropylamine

: 1318128-97-0
4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: In isopropyl alcohol; at 110 ℃; for 15h;

Reference yield:

: 85006-31-1
3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

: 1318128-97-0
4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: 3 h / 200 °C

2: trichlorophosphate / 2 h / 110 °C

3: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 1 h / 100 °C

4: potassium iodide / N,N-dimethyl-formamide / 4 h / 35 °C

5: sodium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

6: manganese(IV) oxide / chloroform / 2 h / 70 °C

7: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide / 0 - 20 °C

8: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

9: ammonia / isopropyl alcohol / 10 h / 70 °C / closed vessel

10: isopropyl alcohol / 15 h / 110 °C

With manganese(IV) oxide; sodium chlorite; N-Bromosuccinimide; sodium dihydrogenphosphate dihydrate; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; sodium hydroxide; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;