cyclohexyl-[6-piperazin-1-yl-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-2'-yl]-amine

Base Information

Chemical Name:cyclohexyl-[6-piperazin-1-yl-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-2'-yl]-amine
CAS No.:1201674-03-4
Molecular Formula:C₂₁H₂₇N₉
Molecular Weight:405.506
Hs Code.:

Synonyms:cyclohexyl-[6-piperazin-1-yl-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-2'-yl]-amine

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Chemical Property of cyclohexyl-[6-piperazin-1-yl-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-2'-yl]-amine

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Technology Process of cyclohexyl-[6-piperazin-1-yl-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-2'-yl]-amine

There total 10 articles about cyclohexyl-[6-piperazin-1-yl-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-2'-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1201675-54-8
4-[2'-cyclohexylamino-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-6-yl]-piperazine-1-carboxylic acid tert-butyl ester

: 1201674-03-4
cyclohexyl-[6-piperazin-1-yl-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-2'-yl]-amine

Guidance literature:: 4-[2'-cyclohexylamino-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-6-yl]-piperazine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 2h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 1201674-86-3
4-(6-bromo-4-methoxycarbonylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

: 1201674-03-4
cyclohexyl-[6-piperazin-1-yl-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-2'-yl]-amine

Guidance literature:: Multi-step reaction with 7 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 4 h / 80 °C

2: ammonia / methanol / 90 °C

3: 130 °C / Neat (no solvent)

4: triethylamine / dichloromethane / 20 °C

5: potassium carbonate / methanol / 0.5 h

6: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 120 °C

7: trifluoroacetic acid / dichloromethane / 2 h

With sodium azide; ammonia; sodium carbonate; potassium carbonate; ammonium chloride; triethylamine; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 99-11-6
citrazinic acid

: 1201674-03-4
cyclohexyl-[6-piperazin-1-yl-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-2'-yl]-amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: phosphorus(V) oxybromide / 130 °C

1.2: 0 °C

2.1: triethylamine / 1,4-dioxane / 110 °C

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 4 h / 80 °C

4.1: ammonia / methanol / 90 °C

5.1: 130 °C / Neat (no solvent)

6.1: triethylamine / dichloromethane / 20 °C

7.1: potassium carbonate / methanol / 0.5 h

8.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 120 °C

9.1: trifluoroacetic acid / dichloromethane / 2 h

With sodium azide; ammonia; sodium carbonate; potassium carbonate; ammonium chloride; triethylamine; trifluoroacetic acid; phosphorus(V) oxybromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;