diethyl 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

Base Information

Chemical Name:diethyl 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate
CAS No.:1345025-20-8
Molecular Formula:C₁₆H₂₅O₈P
Molecular Weight:376.343
Hs Code.:

Synonyms:diethyl 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

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Chemical Property of diethyl 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

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Technology Process of diethyl 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

There total 2 articles about diethyl 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 683-08-9
Diethyl methylphosphonate

: 2,4-bis-methoxymethoxy-benzoic acid methoxymethyl ester

: 1345025-20-8
diethyl 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

Guidance literature:: Diethyl methylphosphonate; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at 0 ℃; for 1h; Inert atmosphere;

2,4-bis-methoxymethoxy-benzoic acid methoxymethyl ester; In tetrahydrofuran; hexane; at 0 ℃; for 20h; Inert atmosphere;
DOI:10.1248/cpb.59.885

Reference yield:

: 89-86-1
4-hydroxysalicylic acid

: 1345025-20-8
diethyl 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 1 h / 0 °C / Inert atmosphere

2.2: 20 h / 0 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1248/cpb.59.885

Reference yield:

: 1345025-20-8
diethyl 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

: 961-29-5,13745-20-5
isoliquirtigenin

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / methanol; water / 1 h / Reflux

2.2: 0.17 h / 20 °C

With hydrogenchloride; sodium hydride; In tetrahydrofuran; methanol; water; mineral oil; 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1248/cpb.59.885