N-[5-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]pentyl]-N-methyltrifluoroacetamide

Base Information

Chemical Name:N-[5-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]pentyl]-N-methyltrifluoroacetamide
CAS No.:261718-62-1
Molecular Formula:C₄₂H₅₆F₃NO₆
Molecular Weight:727.905
Hs Code.:

Synonyms:N-[5-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]pentyl]-N-methyltrifluoroacetamide

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Chemical Property of N-[5-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]pentyl]-N-methyltrifluoroacetamide

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Technology Process of N-[5-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]pentyl]-N-methyltrifluoroacetamide

There total 3 articles about N-[5-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]pentyl]-N-methyltrifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 261718-60-9
N-[5-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]pentyl]trifluoroacetamide

: 74-88-4
methyl iodide

: 261718-62-1
N-[5-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]pentyl]-N-methyltrifluoroacetamide

Guidance literature:: N-[5-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]pentyl]trifluoroacetamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/jm990179s

Reference yield:

: (8S,9R,11S,13S,14S,17S)-11-[4-(5-Iodo-pentyloxy)-phenyl]-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

: 261718-62-1
N-[5-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]pentyl]-N-methyltrifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / p-toluenosulfonic acid / tetrahydrofuran / 1.5 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.33 h

2.2: 40 percent / tetrahydrofuran; dimethylformamide / 5.5 h / 20 °C

3.1: NaH / dimethylformamide / 0.33 h / 20 °C

3.2: 98 percent / tetrahydrofuran / 1 h / 20 °C

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Etherification / 2.1: deprotonation / 2.2: Alkylation / 3.1: deprotonation / 3.2: Methylation;
DOI:10.1021/jm990179s

Reference yield:

: 261718-59-6
3,17β-bis[tetrahydro(2H)-2-pyranyloxy]-11β-[4-[(5-iodopentyl)oxy]phenyl]estra-1,3,5(10)-triene

: 261718-62-1
N-[5-[4-[3,17β-bis[tetrahydro(2H)-2-pyranyloxy]estra-1,3,5(10)-trien-11β-yl]phenoxy]pentyl]-N-methyltrifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.33 h

1.2: 40 percent / tetrahydrofuran; dimethylformamide / 5.5 h / 20 °C

2.1: NaH / dimethylformamide / 0.33 h / 20 °C

2.2: 98 percent / tetrahydrofuran / 1 h / 20 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: deprotonation / 1.2: Alkylation / 2.1: deprotonation / 2.2: Methylation;
DOI:10.1021/jm990179s