(S)-methyl 2-(2-(3-chlorophenyl)-7-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

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Chemical Name:(S)-methyl 2-(2-(3-chlorophenyl)-7-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate
CAS No.:1364598-97-9
Molecular Formula:C₁₉H₂₀ClN₃O₃
Molecular Weight:373.839
Hs Code.:

Synonyms:(S)-methyl 2-(2-(3-chlorophenyl)-7-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

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Chemical Property of (S)-methyl 2-(2-(3-chlorophenyl)-7-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

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Technology Process of (S)-methyl 2-(2-(3-chlorophenyl)-7-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

There total 5 articles about (S)-methyl 2-(2-(3-chlorophenyl)-7-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.9%

: 1364598-94-6
methyl 2-(2-(3-chlorophenyl)-7-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate

: 1364598-97-9
(S)-methyl 2-(2-(3-chlorophenyl)-7-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

Guidance literature:: methyl 2-(2-(3-chlorophenyl)-7-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate; With (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In tetrahydrofuran; toluene; at -35 ℃; for 0.666667h;

With sodium carbonate; In tetrahydrofuran; ethyl acetate; toluene; for 0.5h;

Reference yield:

: 208519-09-9
5-(3-chlorophenyl)-1H-pyrazole-3-amine

: 1364598-97-9
(S)-methyl 2-(2-(3-chlorophenyl)-7-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: o-xylene / 20 h / 155 - 160 °C

2.1: bromine / dichloromethane; methanol / 2.33 h

3.1: N,N-diethylaniline; trichlorophosphate / 16 h / 120 °C

4.1: copper(I) bromide / tetrahydrofuran / 1.08 h

4.2: 1 h

5.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / toluene; tetrahydrofuran / 0.67 h / -35 °C

5.2: 0.5 h

With bromine; N,N-diethylaniline; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; trichlorophosphate; benzo[1,3,2]dioxaborole; copper(I) bromide; In tetrahydrofuran; methanol; dichloromethane; o-xylene; toluene;

Reference yield:

: 332899-44-2
2-(3-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol

: 1364598-97-9
(S)-methyl 2-(2-(3-chlorophenyl)-7-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / dichloromethane; methanol / 2.33 h

2.1: N,N-diethylaniline; trichlorophosphate / 16 h / 120 °C

3.1: copper(I) bromide / tetrahydrofuran / 1.08 h

3.2: 1 h

4.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / toluene; tetrahydrofuran / 0.67 h / -35 °C

4.2: 0.5 h

With bromine; N,N-diethylaniline; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; trichlorophosphate; benzo[1,3,2]dioxaborole; copper(I) bromide; In tetrahydrofuran; methanol; dichloromethane; toluene;