tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino)ethyl)-4-(triisopropylsilyl)-3-butynyl)carbamate

Base Information

Chemical Name:tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino)ethyl)-4-(triisopropylsilyl)-3-butynyl)carbamate
CAS No.:1319744-18-7
Molecular Formula:C₃₆H₄₉N₃O₃Si
Molecular Weight:599.889
Hs Code.:

Synonyms:tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino)ethyl)-4-(triisopropylsilyl)-3-butynyl)carbamate

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Chemical Property of tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino)ethyl)-4-(triisopropylsilyl)-3-butynyl)carbamate

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Technology Process of tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino)ethyl)-4-(triisopropylsilyl)-3-butynyl)carbamate

There total 4 articles about tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino)ethyl)-4-(triisopropylsilyl)-3-butynyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1319744-34-7
tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate

: 111409-79-1
1-bromo-2-(triisopropylsilyl)acetylene

: 1319744-18-7
tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino)ethyl)-4-(triisopropylsilyl)-3-butynyl)carbamate

Guidance literature:: With silver(I) acetate; palladium diacetate; lithium chloride; In toluene; at 110 ℃; for 15h;
DOI:10.1021/ja206002m

Reference yield:

: 89343-06-6
tris-iso-propylsilyl acetylene

: 1319744-18-7
tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino)ethyl)-4-(triisopropylsilyl)-3-butynyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate

2: silver(I) acetate; palladium diacetate; lithium chloride / toluene / 15 h / 110 °C

With N-Bromosuccinimide; silver(I) acetate; palladium diacetate; silver nitrate; lithium chloride; In toluene;
DOI:10.1021/ja206002m

Reference yield:

: 578-66-5
8-amino quinoline

: 1319744-18-7
tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino)ethyl)-4-(triisopropylsilyl)-3-butynyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

2: silver(I) acetate; palladium diacetate; lithium chloride / toluene / 15 h / 110 °C

With silver(I) acetate; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium chloride; In toluene;
DOI:10.1021/ja206002m