tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate

Base Information

• Chemical Name: tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate
• CAS No.: 1319744-34-7
• Molecular Formula: C₂₅H₂₉N₃O₃
• Molecular Weight: 419.524
• Mol file: 1319744-34-7.mol

Synonyms:tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate

Chemical Property of tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate

There total 1 articles about tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-amino quinoline (578-66-5) + 4-{benzyl[(tert-butoxy)carbonyl]amino}butanoic acid (213772-01-1) → tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate (1319744-34-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

DOI:10.1021/ja206002m

Reference yield: 88.0%

[bis(acetoxy)iodo]benzene (3240-34-4) + tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate (1319744-34-7) → tert-butyl benzyl(4-oxo-2-phenyl-4-(quinolin-8-ylamino)-butyl)carbamate

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); caesium carbonate; In 1,3,5-trimethyl-benzene; at 20 - 110 ℃;

DOI:10.1021/acs.joc.5b00111

Reference yield: 85.0%

iodobenzene (591-50-4) + tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate (1319744-34-7) → tert-butyl benzyl(4-oxo-2-phenyl-4-(quinolin-8-ylamino)-butyl)carbamate

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); cesium acetate; In 1,3,5-trimethyl-benzene; at 110 ℃; Sealed tube;

DOI:10.1002/ejoc.201701215

upstream raw materials:

8-amino quinoline

4-{benzyl[(tert-butoxy)carbonyl]amino}butanoic acid

Downstream raw materials:

tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino))ethyl)-3-butynylcarbamate

tert-butyl benzyl(2-(1-(3-(5-(dimethylamino)-1-naphthalenylsulfonyl)aminopropyl)-1H-1,2,3-triazol-4-yl)-4-oxo-4-(8-quinolinylamino)butyl)carbamate

tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino)ethyl)-4-(triisopropylsilyl)-3-butynyl)carbamate