Technology Process of 3'-O-(2-azidomethlbenzoyl)-2'-O-TBDMS-N-Bz-adenosine
There total 8 articles about 3'-O-(2-azidomethlbenzoyl)-2'-O-TBDMS-N-Bz-adenosine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
formic acid;
In
chloroform;
at 20 ℃;
for 0.5h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 1.5 h / Reflux
2.1: sodium azide / ethanol / 20 °C
3.1: sodium hydroxide; water / methanol / 0.5 h / 20 °C
3.2: pH 1
4.1: thionyl chloride / chloroform / 5 h / Reflux
5.1: 1-methyl-1H-imidazole / dichloromethane / 40 h / Cooling with ice
6.1: formic acid / chloroform / 0.5 h / 20 °C / Cooling with ice
With
1-methyl-1H-imidazole; N-Bromosuccinimide; formic acid; thionyl chloride; sodium azide; water; sodium hydroxide; dibenzoyl peroxide;
In
methanol; tetrachloromethane; ethanol; dichloromethane; chloroform;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; water / methanol / 0.5 h / 20 °C
1.2: pH 1
2.1: thionyl chloride / chloroform / 5 h / Reflux
3.1: 1-methyl-1H-imidazole / dichloromethane / 40 h / Cooling with ice
4.1: formic acid / chloroform / 0.5 h / 20 °C / Cooling with ice
With
1-methyl-1H-imidazole; formic acid; thionyl chloride; water; sodium hydroxide;
In
methanol; dichloromethane; chloroform;
