N-{6-{((3S)-3-piperidyl)methyl}amino-6-oxohexyl}-3,3,3-triphenylpropanamide

Base Information

• Chemical Name: N-{6-{((3S)-3-piperidyl)methyl}amino-6-oxohexyl}-3,3,3-triphenylpropanamide
• CAS No.: 323181-99-3
• Molecular Formula: C₃₃H₄₁N₃O₂
• Molecular Weight: 511.707
• Mol file: 323181-99-3.mol

Synonyms:N-{6-{((3S)-3-piperidyl)methyl}amino-6-oxohexyl}-3,3,3-triphenylpropanamide

Chemical Property of N-{6-{((3S)-3-piperidyl)methyl}amino-6-oxohexyl}-3,3,3-triphenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{6-{((3S)-3-piperidyl)methyl}amino-6-oxohexyl}-3,3,3-triphenylpropanamide

There total 6 articles about N-{6-{((3S)-3-piperidyl)methyl}amino-6-oxohexyl}-3,3,3-triphenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-{[6-(3,3,3-triphenyl-propionylamino)-hexanoylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester → N-{6-{((3S)-3-piperidyl)methyl}amino-6-oxohexyl}-3,3,3-triphenylpropanamide (323181-99-3)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 20 ℃;

DOI:10.1021/jm010480k

Reference yield:

methyl 6-aminohexanoate hydrochloride (2780-89-4) → N-{6-{((3S)-3-piperidyl)methyl}amino-6-oxohexyl}-3,3,3-triphenylpropanamide (323181-99-3)

Guidance literature:

Multi-step reaction with 4 steps

1: WSC; HOBt; NEt₃ / CHCl₃ / 20 °C

2: 4N aq. NaOH / methanol; CHCl₃ / 20 °C

3: WSC; HOBt / CHCl₃ / 20 °C

4: TFA / CHCl₃ / 20 °C

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In methanol; chloroform;

DOI:10.1021/jm010480k

Reference yield:

N-tert-butoxycarbonyl-6-aminohexanoic acid methyl ester (128372-97-4) → N-{6-{((3S)-3-piperidyl)methyl}amino-6-oxohexyl}-3,3,3-triphenylpropanamide (323181-99-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 10percent aq. HCl / methanol

2: WSC; HOBt; NEt₃ / CHCl₃ / 20 °C

3: 4N aq. NaOH / methanol; CHCl₃ / 20 °C

4: WSC; HOBt / CHCl₃ / 20 °C

5: TFA / CHCl₃ / 20 °C

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In methanol; chloroform;

DOI:10.1021/jm010480k

upstream raw materials:

methyl 6-aminohexanoate hydrochloride

N-tert-butoxycarbonyl-6-aminohexanoic acid methyl ester

6-(3,3,3-triphenyl-propionylamino)-hexanoic acid

6-(3,3,3-triphenyl-propionylamino)-hexanoic acid methyl ester