Technology Process of Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester
There total 1 articles about Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
N,N-dimethyl-formamide;
for 120h;
Ambient temperature;
- Guidance literature:
-
N-tert-butoxycarbonyl-6-aminohexanoic acid methyl ester;
With
diisobutylaluminium hydride;
In
dichloromethane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
phenylsulfonylnitromethane;
With
ester of 3,5-di-tert-butyl-4-hydroxyphenylpropionic acid and pentaerythritol; L-proline;
In
dimethyl sulfoxide;
at 20 ℃;
for 48h;
DOI:10.1016/j.tet.2019.130883
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 10percent aq. HCl / methanol
2: WSC; HOBt; NEt3 / CHCl3 / 20 °C
3: 4N aq. NaOH / methanol; CHCl3 / 20 °C
With
sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
In
methanol; chloroform;
DOI:10.1021/jm010480k
