(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide
CAS No.:1365530-29-5
Molecular Formula:C₂₃H₂₂ClF₄N₃OS
Molecular Weight:499.96
Hs Code.:

Synonyms:(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide

There total 4 articles about (R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89809-64-3
2-cyano-5-chloropyridine

: 1365530-29-5
(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide

: 939426-07-0
(R)-N-((R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 14 h / 75 °C

3.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

With titanium(IV) tetraethanolate; n-butyllithium; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.tet.2012.01.050

Reference yield:

: 109-06-8
α-picoline

: 939039-30-2
C₁₇H₁₅ClF₄N₂OS

: 1365530-29-5
(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide

: 939426-07-0
(R)-N-((R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: α-picoline; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.666667h; Inert atmosphere;

C₁₇H₁₅ClF₄N₂OS; In tetrahydrofuran; at -78 ℃; for 2h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2012.01.050

Reference yield:

: 939039-29-9
(5-chloropyridin-2-yl)(3-fluoro-5-(trifluoromethyl)phenyl)methanone

: 1365530-29-5
(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide

: 939426-07-0
(R)-N-((R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 14 h / 75 °C

2.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

With titanium(IV) tetraethanolate; n-butyllithium; In tetrahydrofuran;
DOI:10.1016/j.tet.2012.01.050