(2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol

Base Information

• Chemical Name: (2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol
• CAS No.: 125414-45-1
• Molecular Formula: C₁₄H₂₁NO₄
• Molecular Weight: 267.325
• Mol file: 125414-45-1.mol

Synonyms:(2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol

Chemical Property of (2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol

There total 14 articles about (2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

di-tert-butyl dicarbonate (24424-99-5) + (1R,2R)-3-amino-3-phenyl-1,2-propanediol (153829-27-7) → (2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol (125414-45-1)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; for 8h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88039-X

Reference yield: 90.0%

di-tert-butyl dicarbonate (24424-99-5) + (2R,3R)-3-diphenylmethylamino-3-phenyl-1,2-diol (138611-12-8) → (2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol (125414-45-1)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethyl acetate;

DOI:10.1016/S0040-4039(00)61565-4

Reference yield: 68.0%

C19H26N2O5 → (2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol (125414-45-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol;

DOI:10.1021/acscatal.9b03394

upstream raw materials:

di-tert-butyl dicarbonate

(1S,2S)-2-amino-1-phenyl-1,3-propanediol

(2R,3R)-3-diphenylmethylamino-3-phenyl-1,2-diol

(1R,2R)-3-amino-3-phenyl-1,2-propanediol

Downstream raw materials:

(6S,7R)-2,2,3,3,11,11-hexamethyl-9-oxo-7-phenyl-4,10-dioxa-8-aza-3-siladodecan-6-yl 4-nitrobenzoate

methyl (3S)-3-[(tert-butoxycarbonyl)amino]-3-phenylpropionate

S-(3-hydroxy-1-phenyl-propyl)-carbamic acid tert-butyl ester

tert-butyl [(1S)-1-phenylprop-2-en-1-yl]imidocarbonate