5-Chloro-3-dimethylamino-2-methoxy-benzoic acid ethyl ester

Base Information

• Chemical Name: 5-Chloro-3-dimethylamino-2-methoxy-benzoic acid ethyl ester
• CAS No.: 177212-78-1
• Molecular Formula: C₁₂H₁₆ClNO₃
• Molecular Weight: 257.717
• Mol file: 177212-78-1.mol

Synonyms:5-Chloro-3-dimethylamino-2-methoxy-benzoic acid ethyl ester

Chemical Property of 5-Chloro-3-dimethylamino-2-methoxy-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Chloro-3-dimethylamino-2-methoxy-benzoic acid ethyl ester

There total 1 articles about 5-Chloro-3-dimethylamino-2-methoxy-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

ethyl 3-aminio-5-chloro-2-hydroxybenzoate (149140-78-3) + methyl iodide (74-88-4) → 5-Chloro-3-dimethylamino-2-methoxy-benzoic acid ethyl ester (177212-78-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 - 75 ℃; for 3h;

DOI:10.1248/cpb.44.756

Reference yield: 70.0%

5-Chloro-3-dimethylamino-2-methoxy-benzoic acid ethyl ester (177212-78-1) → 5-chloro-3-dimethylamino-2-methoxybenzoic acid (177212-79-2)

Guidance literature:

With sodium hydroxide; In methanol; Ambient temperature;

DOI:10.1248/cpb.44.756

Reference yield:

5-Chloro-3-dimethylamino-2-methoxy-benzoic acid ethyl ester (177212-78-1) → C15H20ClNO4

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / aq. NaOH / methanol / Ambient temperature

2: Et₃N / ethyl acetate / 0.5 h / -10 - -5 °C

With sodium hydroxide; triethylamine; In methanol; ethyl acetate;

DOI:10.1248/cpb.44.756

upstream raw materials:

ethyl 3-aminio-5-chloro-2-hydroxybenzoate

methyl iodide

Downstream raw materials:

5-chloro-3-dimethylamino-2-methoxybenzoic acid