N-[5-ethyl-6-methyl-4-(3-methyl-benzyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-formamide

Base Information

• Chemical Name: N-[5-ethyl-6-methyl-4-(3-methyl-benzyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-formamide
• CAS No.: 858344-86-2
• Molecular Formula: C₁₇H₂₀N₂O₂
• Molecular Weight: 284.358
• Mol file: 858344-86-2.mol

Synonyms:N-[5-ethyl-6-methyl-4-(3-methyl-benzyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-formamide

Chemical Property of N-[5-ethyl-6-methyl-4-(3-methyl-benzyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-formamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[5-ethyl-6-methyl-4-(3-methyl-benzyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-formamide

There total 1 articles about N-[5-ethyl-6-methyl-4-(3-methyl-benzyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

formic acid ethyl ester (109-94-4) + 3-amino-5-ethyl-6-methyl-4-[(3-methylphenyl)methyl]pyridin-2(1H)-one (248247-00-9) → N-[5-ethyl-6-methyl-4-(3-methyl-benzyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-formamide (858344-86-2)

Guidance literature:

With acetic acid; for 4h; Heating;

DOI:10.1021/jm0408621

Reference yield: 46.0%

N-[5-ethyl-6-methyl-4-(3-methyl-benzyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-formamide (858344-86-2) → 5-ethyl-6-methyl-3-(methylamino)-4-(3-methylbenzyl)pyridin-2(1H)-one (847741-27-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/jm0408621

Reference yield:

N-[5-ethyl-6-methyl-4-(3-methyl-benzyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-formamide (858344-86-2) → {[5-ethyl-6-methyl-4-(3-methyl-benzyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-methyl-amino}-acetonitrile

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

2: 28 percent / Et₃N / dimethylformamide / 100 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm0408621

upstream raw materials:

formic acid ethyl ester

3-amino-5-ethyl-6-methyl-4-[(3-methylphenyl)methyl]pyridin-2(1H)-one

Downstream raw materials:

5-ethyl-6-methyl-3-(methylamino)-4-(3-methylbenzyl)pyridin-2(1H)-one