O-p-trifluoromethylbenzenesulfonyl benzyloxyhydroxamate

Base Information

• Chemical Name: O-p-trifluoromethylbenzenesulfonyl benzyloxyhydroxamate
• CAS No.: 1219619-42-7
• Molecular Formula: C₁₅H₁₂F₃NO₅S
• Molecular Weight: 375.325
• Mol file: 1219619-42-7.mol

Synonyms:O-p-trifluoromethylbenzenesulfonyl benzyloxyhydroxamate

Chemical Property of O-p-trifluoromethylbenzenesulfonyl benzyloxyhydroxamate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of O-p-trifluoromethylbenzenesulfonyl benzyloxyhydroxamate

There total 1 articles about O-p-trifluoromethylbenzenesulfonyl benzyloxyhydroxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.4%

Benzyl N-hydroxycarbamate (3426-71-9) + 4-trifluorophenylsulfonyl chloride (2991-42-6) → O-p-trifluoromethylbenzenesulfonyl benzyloxyhydroxamate (1219619-42-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -15 ℃; for 0.5h;

DOI:10.1080/00397910903007111

Reference yield: 99.0%

O-p-trifluoromethylbenzenesulfonyl benzyloxyhydroxamate (1219619-42-7) → O-p-trifluoromethylbenzenesulfonylhydroxylamine (1219619-46-1)

Guidance literature:

With 10% palladium on activated carbon; hydrogen; In methanol; at 20 ℃; for 0.5h;

DOI:10.1080/00397910903007111

Reference yield: 81.0%

O-p-trifluoromethylbenzenesulfonyl benzyloxyhydroxamate (1219619-42-7) + N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide (243844-35-1) → benzyl 1-tosyl-1,3-dihydro-2H-indazole-2-carboxylate

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 8h;

DOI:10.1002/adsc.201901331

upstream raw materials:

Benzyl N-hydroxycarbamate

4-trifluorophenylsulfonyl chloride

Downstream raw materials:

O-p-trifluoromethylbenzenesulfonylhydroxylamine