243844-35-1

Basic information

• Product Name: N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide
• Synonyms: N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide
• CAS NO: 243844-35-1
• Molecular Weight: 295.79
• Mol File: 243844-35-1.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide(243844-35-1)
• EPA Substance Registry System: N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide(243844-35-1)

Safety Data

• Hazardous Substances Data: 243844-35-1(Hazardous Substances Data)

Upstream product

• 90312-02-0 N-(2-hydroxymethylphenyl)-4-methylbenzenesulfonamide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 98-59-9 p-toluenesulfonyl chloride 
• 118-92-3 anthranilic acid 
• 17849-38-6 2-Chlorobenzyl alcohol 

Downstream Products

• 1269261-63-3 2-(bromomethyl)-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline 
• 3770-50-1 2-carbethoxyindole 
• 1464963-64-1 ethyl 2-acetyl-1-tosylindoline-2-carboxylate 
• 1464963-65-2 1-(2-benzoyl-1-tosylindolin-2-yl)ethanone 
• 1464963-71-0 allyl 2-acetyl-1-tosylindoline-2-carboxylate 
• 1464963-74-3 benzyl 2-acetyl-1-tosylindoline-2-carboxylate 
• 1464963-76-5 tert-butyl 2-acetyl-1-tosylindoline-2-carboxylate 
• 1464963-78-7 methyl 2-(cyclopropanecarbonyl)-1-tosylindoline-2-carboxylate 
• 1464963-81-2 ethyl 2-benzoyl-1-tosylindoline-2-carboxylate 
• 1464963-83-4 ethyl 2-(2-chloroacetyl)-1-tosylindoline-2-carboxylate 
• 1464963-85-6 methyl 2-(2-methoxyacetyl)-1-tosylindoline-2-carboxylate 
• 1464963-88-9 dimethyl 1-tosylindoline-2,2-dicarboxylate 
• 1464963-90-3 ethyl 2-cyano-1-tosylindoline-2-carboxylate 
• 1464963-92-5 1,1'-(1-tosylindoline-2,2-diyl)diethanone 

Relevant articles and documents

A [4+3] Cycloaddition Reaction of Aza-ortho-quinone Methides with C,N-Cyclic Azomethine Imines for Synthesis of 1,2,4-Triazepines

The base-induced formal [4+3] cycloaddition reaction of C,N-cyclic azomethine imines with aza-ortho-quinone methides, generated in situ, is reported. This protocol provided an efficient method for the synthesis of biologically important 1,2,4-triazepine derivatives, with a wide substrate scope and excellent functional-group tolerance, and it gives moderate to excellent yields under mild conditions. Several of the derivatives exhibited in vitro antitumor activities against the A2780 cell line in a screening of the cancer cell lines HCT-116, H2228, and A2780 by an MTT assay.

Benzoazacyclo compound and application thereof

The invention discloses a compound represented by a formula (I) or a salt thereof. The invention further provides an application of the compound represented by the formula (I) or the salt thereof in preparation of drugs for preventing or treating hepatic fibrosis diseases. The invention provides a new benzoazacyclo compound or a salt thereof, and it is found that the benzoazacyclo compound has anobvious anti-hepatic fibrosis effect for the first time, and thus a new application of the benzoazacyclo compound in preparation of drugs for preventing hepatic fibrosis diseases or treating hepatic fibrosis diseases is found out.

Palladium(II)-catalyzed aerobic intramolecular allylic C[sbnd]H activation for the synthesis of indolines

A method for the preparation of indolines via palladium-catalyzed aerobic intramolecular allylic C[sbnd]H activation was developed. Oxygen was successfully used as oxidant with catalytic amount of 1,4-benzoquinone. 16 examples were reported, the majority of substrates gave moderate to good yields.