(1S,2S)-2-phenyl-cyclopropanecarboxylic acid [(S)-1-(4'-methoxy-biphenyl-4-yl)propyl]amide

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Chemical Name:(1S,2S)-2-phenyl-cyclopropanecarboxylic acid [(S)-1-(4'-methoxy-biphenyl-4-yl)propyl]amide
CAS No.:1286280-27-0
Molecular Formula:C₂₆H₂₇NO₂
Molecular Weight:385.506
Hs Code.:

Synonyms:(1S,2S)-2-phenyl-cyclopropanecarboxylic acid [(S)-1-(4'-methoxy-biphenyl-4-yl)propyl]amide

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Chemical Property of (1S,2S)-2-phenyl-cyclopropanecarboxylic acid [(S)-1-(4'-methoxy-biphenyl-4-yl)propyl]amide

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Technology Process of (1S,2S)-2-phenyl-cyclopropanecarboxylic acid [(S)-1-(4'-methoxy-biphenyl-4-yl)propyl]amide

There total 3 articles about (1S,2S)-2-phenyl-cyclopropanecarboxylic acid [(S)-1-(4'-methoxy-biphenyl-4-yl)propyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1286280-45-2
(1S,2S)-2-phenyl-cyclopropanecarboxylic acid [(S)-1-(4-bromo-phenyl)propyl]amide

: 5720-07-0
4-methoxyphenylboronic acid

: 1286280-27-0
(1S,2S)-2-phenyl-cyclopropanecarboxylic acid [(S)-1-(4'-methoxy-biphenyl-4-yl)propyl]amide

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 160 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

: 23020-15-7
(1S,2S)-2-phenylcyclopropane-1-carboxylic acid

: 1286280-27-0
(1S,2S)-2-phenyl-cyclopropanecarboxylic acid [(S)-1-(4'-methoxy-biphenyl-4-yl)propyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.75 h / 20 °C

2: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

3: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.08 h / 160 °C / Microwave irradiation

With potassium phosphate; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; 3: Suzuki Coupling;

Reference yield:

: 78738-39-3
trans-2-phenyl-1-cyclopropanecarbonyl chloride

: 1286280-27-0
(1S,2S)-2-phenyl-cyclopropanecarboxylic acid [(S)-1-(4'-methoxy-biphenyl-4-yl)propyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

2: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.08 h / 160 °C / Microwave irradiation

With potassium phosphate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; 2: Suzuki Coupling;