N-[3-benzyl-5-oxo-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydro-pyrazin-2-yl]-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-[3-benzyl-5-oxo-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydro-pyrazin-2-yl]-4-methyl-benzenesulfonamide
CAS No.:671240-59-8
Molecular Formula:C₂₅H₂₅N₃O₅S₂
Molecular Weight:511.623
Hs Code.:

<i>N</i>-[3-benzyl-5-oxo-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydro-pyrazin-2-yl]-4-methyl-benzenesulfonamide

Synonyms:N-[3-benzyl-5-oxo-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydro-pyrazin-2-yl]-4-methyl-benzenesulfonamide

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Chemical Property of N-[3-benzyl-5-oxo-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydro-pyrazin-2-yl]-4-methyl-benzenesulfonamide

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Technology Process of N-[3-benzyl-5-oxo-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydro-pyrazin-2-yl]-4-methyl-benzenesulfonamide

There total 4 articles about N-[3-benzyl-5-oxo-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydro-pyrazin-2-yl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93554-83-7
α-aminophenylpropiononitrile hydrochloride

: 671240-59-8
N-[3-benzyl-5-oxo-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydro-pyrazin-2-yl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / hydroxybenzotriazole; EDC; pyridine / CH₂Cl₂ / 15 h / 20 °C

2: CH₂Cl₂ / 1.5 h / 0 °C

3: NH₂OH*HCl; Na₂CO₃ / ethanol; H₂O / 19 h / 20 - 70 °C

4: H₂ / Raney-Ni W₂ / methanol / 3 h / 20 °C / atmospheric pressure

5: pyridine / 1 h / 20 °C

With pyridine; hydroxylamine hydrochloride; hydrogen; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; Raney-Ni W₂; In methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2003.11.052

Reference yield:

: 671240-57-6
3-benzyl-piperazine-2,5-dione 2-oxime

: 671240-59-8
N-[3-benzyl-5-oxo-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydro-pyrazin-2-yl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Raney-Ni W₂ / methanol / 3 h / 20 °C / atmospheric pressure

2: pyridine / 1 h / 20 °C

With pyridine; hydrogen; Raney-Ni W₂; In methanol;
DOI:10.1016/j.tet.2003.11.052

Reference yield:

: 2-amino-N-(1-cyano-2-phenyl-ethyl)-acetamide; compound with trifluoro-acetic acid

: 671240-59-8
N-[3-benzyl-5-oxo-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydro-pyrazin-2-yl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: NH₂OH*HCl; Na₂CO₃ / ethanol; H₂O / 19 h / 20 - 70 °C

2: H₂ / Raney-Ni W₂ / methanol / 3 h / 20 °C / atmospheric pressure

3: pyridine / 1 h / 20 °C

With pyridine; hydroxylamine hydrochloride; hydrogen; sodium carbonate; Raney-Ni W₂; In methanol; ethanol; water;
DOI:10.1016/j.tet.2003.11.052