2-[4-(cyclopropylsulfonyl)phenyl]-3-[(1r,3R,4S)-3,4-difluorocyclopentyl]acrylic acid

Base Information

Chemical Name:2-[4-(cyclopropylsulfonyl)phenyl]-3-[(1r,3R,4S)-3,4-difluorocyclopentyl]acrylic acid
CAS No.:1193394-15-8
Molecular Formula:C₁₇H₁₈F₂O₄S
Molecular Weight:356.39
Hs Code.:

Synonyms:2-[4-(cyclopropylsulfonyl)phenyl]-3-[(1r,3R,4S)-3,4-difluorocyclopentyl]acrylic acid

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Chemical Property of 2-[4-(cyclopropylsulfonyl)phenyl]-3-[(1r,3R,4S)-3,4-difluorocyclopentyl]acrylic acid

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Technology Process of 2-[4-(cyclopropylsulfonyl)phenyl]-3-[(1r,3R,4S)-3,4-difluorocyclopentyl]acrylic acid

There total 2 articles about 2-[4-(cyclopropylsulfonyl)phenyl]-3-[(1r,3R,4S)-3,4-difluorocyclopentyl]acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1193394-13-6
(E)-2-[4-(cyclopropylsulfonyl)phenyl]-3-[(1α,3α,4α)-3,4-difluorocyclopentyl]acrylic acid ethyl ester

: 1193394-15-8
2-[4-(cyclopropylsulfonyl)phenyl]-3-[(1r,3R,4S)-3,4-difluorocyclopentyl]acrylic acid

Guidance literature:: With sulfuric acid; In water; acetic acid; at 98 ℃; for 6h;

Reference yield:

: 745052-94-2
ethyl 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetate

: 2-({[(1r,3R,4S)-3,4-difluorocyclopentyl]methyl}sulfonyl)-1,3-benzothiazole

: 1193394-15-8
2-[4-(cyclopropylsulfonyl)phenyl]-3-[(1r,3R,4S)-3,4-difluorocyclopentyl]acrylic acid

: 2-[4-(cyclopropylsulfonyl)phenyl]-3-[(1r,3R,4S)-3,4-difluorocyclopentyl]acrylic acid

Guidance literature:: ethyl 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetate; 2-({[(1r,3R,4S)-3,4-difluorocyclopentyl]methyl}sulfonyl)-1,3-benzothiazole; With lithium hexamethyldisilazane; In tetrahydrofuran; at -15 - -10 ℃; for 2h;

With sulfuric acid; dihydrogen peroxide; In water; acetic acid; at 50 - 55 ℃; for 3h;

With sulfuric acid; In water; acetic acid; at 80 - 102 ℃; for 6h; Overall yield = 77 percent; Overall yield = 95 g;
DOI:10.1021/acs.oprd.0c00180